Proenkephalin Gene Regulation in Hypothalamic Neurons

Borsook, David

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute on Drug Abuse (NIDA)
• Type: First Independent Research Support & Transition (FIRST) Awards (R29)
• Project #: 5R29DA009565-02
• Application #: 2122882
• Study Section: Drug Abuse Biomedical Research Review Committee (DABR)
• Project Start: 1995-03-15
• Project End: 2000-02-29
• Budget Start: 1996-03-01
• Budget End: 1997-02-28
• Support Year: 2
• Fiscal Year: 1996

Institution

• Name: Massachusetts General Hospital
• City: Boston
• State: MA
• Country: United States
• Zip Code: 02199

Publications

Kobierski, L A; Srivastava, S; Borsook, D (2000) Systemic lipopolysaccharide and interleukin-1beta activate the interleukin 6: STAT intracellular signaling pathway in neurons of mouse trigeminal ganglion. Neurosci Lett 281:61-4

Borsook, D; Smirnova, O; Behar, O et al. (1999) PhosphoCREB and CREM/ICER: positive and negative regulation of proenkephalin gene expression in the paraventricular nucleus of the hypothalamus. J Mol Neurosci 12:35-51

Van Koughnet, K; Smirnova, O; Hyman, S E et al. (1999) Proenkephalin transgene regulation in the paraventricular nucleus of the hypothalamus by lipopolysaccharide and interleukin-1beta. J Comp Neurol 405:199-215

Borsook, D; Falkowski, O; Smirnova, O (1998) Proenkephalin gene regulation in the paraventricular nucleus by GABA: interactions with opioid systems in a transgenic model. J Neurochem 70:604-16

Borsook, D; Hyman, S E (1995) Proenkephalin gene regulation in the neuroendocrine hypothalamus: a model of gene regulation in the CNS. Am J Physiol 269:E393-408