Evoked otoacoustic emissions (OAE) are produced by active processes in the inner ear by interactions with external tones, and provide important data for modeling the mechanisms of hearing. The existence of spontaneous otoacoustic emissions (SOAE), while themselves apparently having no direct role in hearing, pose a problem that any realistic model of the cochlea must account for. A model of the auditory periphery is proposed to account for the large body of data on OAEs, which will have a profound impact on the hearing research carried out by this Purdue group. The model connects apparently disparate phenomenon in a mathematically rigorous fashion, and thus guides the scope of specific experiments and suggests new experiments. The models have significance for the clinical use of SOAEs and evoked OAEs in hearing assessment, particularly for distortion product OAEs, since the question of understanding the underlying mechanisms has an impact on how results should be interpreted clinically. It is expected that the model will play an important role on the group's future research in clinical applications of evoked OAEs.

National Institute of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
First Independent Research Support & Transition (FIRST) Awards (R29)
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Hearing Research Study Section (HAR)
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Purdue University
Schools of Arts and Sciences
West Lafayette
United States
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Dhar, Sumitrajit; Long, Glenis R; Talmadge, Carrick L et al. (2005) The effect of stimulus-frequency ratio on distortion product otoacoustic emission components. J Acoust Soc Am 117:3766-76
Shera, Christopher A; Tubis, Arnold; Talmadge, Carrick L (2004) Do forward- and backward-traveling waves occur within the cochlea? Countering the critique of Nobili et al. J Assoc Res Otolaryngol 5:349-59
Withnell, Robert H; Shaffer, Lauren A; Talmadge, Carrick L (2003) Generation of DPOAEs in the guinea pig. Hear Res 178:106-17
Dhar, Sumitrajit; Talmadge, Carrick L; Long, Glenis R et al. (2002) Multiple internal reflections in the cochlea and their effect on DPOAE fine structure. J Acoust Soc Am 112:2882-97
Tubis, A; Talmadge, C L; Tong, C et al. (2000) On the relationships between the fixed-f1, fixed-f2, and fixed-ratio phase derivatives of the 2f1-f2 distortion product otoacoustic emission. J Acoust Soc Am 108:1772-85
Tubis, A; Talmadge, C L; Tong, C (2000) Modeling the temporal behavior of distortion product otoacoustic emissions. J Acoust Soc Am 107:2112-27
Talmadge, C L; Tubis, A; Long, G R et al. (2000) Modeling the combined effects of basilar membrane nonlinearity and roughness on stimulus frequency otoacoustic emission fine structure. J Acoust Soc Am 108:2911-32
Shera, C A; Talmadge, C L; Tubis, A (2000) Interrelations among distortion-product phase-gradient delays: their connection to scaling symmetry and its breaking. J Acoust Soc Am 108:2933-48
Talmadge, C L; Long, G R; Tubis, A et al. (1999) Experimental confirmation of the two-source interference model for the fine structure of distortion product otoacoustic emissions. J Acoust Soc Am 105:275-92
Talmadge, C L; Tubis, A; Long, G R et al. (1998) Modeling otoacoustic emission and hearing threshold fine structures. J Acoust Soc Am 104:1517-43

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