Intestinal and Colonic Cytochrome P450 Gene Expression

Traber, Peter G.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: First Independent Research Support & Transition (FIRST) Awards (R29)
• Project #: 5R29DK041393-04
• Application #: 3463809
• Study Section: Physical Biochemistry Study Section (PB)
• Project Start: 1989-04-01
• Project End: 1992-09-11
• Budget Start: 1992-04-01
• Budget End: 1992-09-11
• Support Year: 4
• Fiscal Year: 1992

Institution

• Name: University of Michigan Ann Arbor
• Type: Schools of Medicine
• DUNS #: 791277940
• City: Ann Arbor
• State: MI
• Country: United States
• Zip Code: 48109

Publications

Markowitz, A J; Wu, G D; Birkenmeier, E H et al. (1993) The human sucrase-isomaltase gene directs complex patterns of gene expression in transgenic mice. Am J Physiol 265:G526-39

Wu, G D; Beer, D G; Moore, J H et al. (1993) Sucrase-isomaltase gene expression in Barrett's esophagus and adenocarcinoma. Gastroenterology 105:837-44

McDonnell, W M; Scheiman, J M; Traber, P G (1992) Induction of cytochrome P450IA genes (CYP1A) by omeprazole in the human alimentary tract. Gastroenterology 103:1509-16

Traber, P G; McDonnell, W M; Wang, W et al. (1992) Expression and regulation of cytochrome P-450I genes (CYP1A1 and CYP1A2) in the rat alimentary tract. Biochim Biophys Acta 1171:167-75

Traber, P G; Wu, G D; Wang, W (1992) Novel DNA-binding proteins regulate intestine-specific transcription of the sucrase-isomaltase gene. Mol Cell Biol 12:3614-27

Wu, G D; Wang, W; Traber, P G (1992) Isolation and characterization of the human sucrase-isomaltase gene and demonstration of intestine-specific transcriptional elements. J Biol Chem 267:7863-70

Traber, P G; Wang, W; Yu, L (1992) Differential regulation of cytochrome P-450 genes along rat intestinal crypt-villus axis. Am J Physiol 263:G215-23

Traber, P G; Yu, L; Wu, G D et al. (1992) Sucrase-isomaltase gene expression along crypt-villus axis of human small intestine is regulated at level of mRNA abundance. Am J Physiol 262:G123-30

Traber, P G; Gumucio, D L; Wang, W (1991) Isolation of intestinal epithelial cells for the study of differential gene expression along the crypt-villus axis. Am J Physiol 260:G895-903

Traber, P G (1990) Regulation of sucrase-isomaltase gene expression along the crypt-villus axis of rat small intestine. Biochem Biophys Res Commun 173:765-73