Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29DK041876-04
Application #
3463926
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1989-08-01
Project End
1992-09-29
Budget Start
1992-08-01
Budget End
1992-09-29
Support Year
4
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
City
Rochester
State
MN
Country
United States
Zip Code
55905
Hirsova, Petra; Ibrahim, Samar H; Krishnan, Anuradha et al. (2016) Lipid-Induced Signaling Causes Release of Inflammatory Extracellular Vesicles From Hepatocytes. Gastroenterology 150:956-67
Ibrahim, Samar H; Hirsova, Petra; Tomita, Kyoko et al. (2016) Mixed lineage kinase 3 mediates release of C-X-C motif ligand 10-bearing chemotactic extracellular vesicles from lipotoxic hepatocytes. Hepatology 63:731-44
Verma, Vikas K; Li, Haiyang; Wang, Ruisi et al. (2016) Alcohol stimulates macrophage activation through caspase-dependent hepatocyte derived release of CD40L containing extracellular vesicles. J Hepatol 64:651-60
Idrissova, Leila; Malhi, Harmeet; Werneburg, Nathan W et al. (2015) TRAIL receptor deletion in mice suppresses the inflammation of nutrient excess. J Hepatol 62:1156-63
Hirsova, Petra; Gores, Gregory J (2015) Ballooned hepatocytes, undead cells, sonic hedgehog, and vitamin E: therapeutic implications for nonalcoholic steatohepatitis. Hepatology 61:15-7
Yu, Tianzheng; Wang, Li; Lee, Hakjoo et al. (2014) Decreasing mitochondrial fission prevents cholestatic liver injury. J Biol Chem 289:34074-88
Ibrahim, Samar H; Gores, Gregory J; Hirsova, Petra et al. (2014) Mixed lineage kinase 3 deficient mice are protected against the high fat high carbohydrate diet-induced steatohepatitis. Liver Int 34:427-37
Bhat, Mamatha; Sonenberg, Nahum; Gores, Gregory J (2013) The mTOR pathway in hepatic malignancies. Hepatology 58:810-8
Kakisaka, Keisuke; Cazanave, Sophie C; Fingas, Christian D et al. (2012) Mechanisms of lysophosphatidylcholine-induced hepatocyte lipoapoptosis. Am J Physiol Gastrointest Liver Physiol 302:G77-84
Ibrahim, Samar H; Gores, Gregory J (2012) Who pulls the trigger: JNK activation in liver lipotoxicity? J Hepatol 56:17-9

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