Pregolgi Degradation of Mutant Secretory Proteins

Sifers, Richard Norman

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: First Independent Research Support & Transition (FIRST) Awards (R29)
• Project #: 3R29DK042806-05S1
• Application #: 2142555
• Study Section: Molecular Cytology Study Section (CTY)
• Project Start: 1991-05-01
• Project End: 1996-10-31
• Budget Start: 1996-05-01
• Budget End: 1996-10-31
• Support Year: 5
• Fiscal Year: 1996

Institution

• Name: Baylor College of Medicine
• Department: Pathology
• Type: Schools of Medicine
• DUNS #: 074615394
• City: Houston
• State: TX
• Country: United States
• Zip Code: 77030

Publications

Le, A; Steiner, J L; Ferrell, G A et al. (1994) Association between calnexin and a secretion-incompetent variant of human alpha 1-antitrypsin. J Biol Chem 269:7514-9

Le, A; Ferrell, G A; Dishon, D S et al. (1992) Soluble aggregates of the human PiZ alpha 1-antitrypsin variant are degraded within the endoplasmic reticulum by a mechanism sensitive to inhibitors of protein synthesis. J Biol Chem 267:1072-80