National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
Application #
Study Section
Endocrinology Study Section (END)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
East Carolina University
Schools of Medicine
United States
Zip Code
Flynn, T R; Hollenberg, A N; Cohen, O et al. (1994) A novel C-terminal domain in the thyroid hormone receptor selectively mediates thyroid hormone inhibition. J Biol Chem 269:32713-6
Usala, S J (1994) Resistance to thyroid hormone in children. Curr Opin Pediatr 6:468-75
Hao, E; Menke, J B; Smith, A M et al. (1994) Divergent dimerization properties of mutant beta 1 thyroid hormone receptors are associated with different dominant negative activities. Mol Endocrinol 8:841-51
Geffner, M E; Su, F; Ross, N S et al. (1993) An arginine to histidine mutation in codon 311 of the C-erbA beta gene results in a mutant thyroid hormone receptor that does not mediate a dominant negative phenotype. J Clin Invest 91:538-46
Klann, R C; Torres, B; Menke, J B et al. (1993) Competitive polymerase chain reaction quantitation of c-erbA beta 1, c-erbA alpha 1, and c-erbA alpha 2 messenger ribonucleic acid levels in normal, heterozygous, and homozygous fibroblasts of kindred S with thyroid hormone resistance. J Clin Endocrinol Metab 77:969-75
Ways, D K; Qin, W; Cook, P et al. (1993) Dominant and nondominant negative C-erbA beta 1 receptors associated with thyroid hormone resistance syndromes augment 12-O-tetradecanoyl-phorbol-13-acetate induction of the collagenase promoter and exhibit defective 3,5,3'-triiodothyronine-mediated repre Mol Endocrinol 7:1112-20
Refetoff, S; Weiss, R E; Usala, S J (1993) The syndromes of resistance to thyroid hormone. Endocr Rev 14:348-99
Meier, C A; Dickstein, B M; Ashizawa, K et al. (1992) Variable transcriptional activity and ligand binding of mutant beta 1 3,5,3'-triiodothyronine receptors from four families with generalized resistance to thyroid hormone. Mol Endocrinol 6:248-58
Cugini Jr, C D; Leidy Jr, J W; Chertow, B S et al. (1992) An arginine to histidine mutation in codon 315 of the c-erbA beta thyroid hormone receptor in a kindred with generalized resistance to thyroid hormones results in a receptor with significant 3,5,3'-triiodothyronine binding activity. J Clin Endocrinol Metab 74:1164-70
Burman, K D; Djuh, Y Y; Nicholson, D et al. (1992) Generalized thyroid hormone resistance: identification of an arginine to cystine mutation in codon 315 of the c-erb A beta thyroid hormone receptor. J Endocrinol Invest 15:573-9

Showing the most recent 10 out of 13 publications