Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29DK043778-05
Application #
2143281
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1991-06-15
Project End
1997-05-31
Budget Start
1995-06-01
Budget End
1997-05-31
Support Year
5
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Nath, S K; Kambadur, R; Yun, C H et al. (1999) NHE2 contains subdomains in the COOH terminus for growth factor and protein kinase regulation. Am J Physiol 276:C873-82
Janecki, A J; Montrose, M H; Tse, C M et al. (1999) Development of an endogenous epithelial Na(+)/H(+) exchanger (NHE3) in three clones of caco-2 cells. Am J Physiol 277:G292-305
Wormmeester, L; Sanchez de Medina, F; Kokke, F et al. (1998) Quantitative contribution of NHE2 and NHE3 to rabbit ileal brush-border Na+/H+ exchange. Am J Physiol 274:C1261-72
Janecki, A J; Montrose, M H; Zimniak, P et al. (1998) Subcellular redistribution is involved in acute regulation of the brush border Na+/H+ exchanger isoform 3 in human colon adenocarcinoma cell line Caco-2. Protein kinase C-mediated inhibition of the exchanger. J Biol Chem 273:8790-8
Yip, J W; Ko, W H; Viberti, G et al. (1997) Regulation of the epithelial brush border Na+/H+ exchanger isoform 3 stably expressed in fibroblasts by fibroblast growth factor and phorbol esters is not through changes in phosphorylation of the exchanger. J Biol Chem 272:18473-80
Hoogerwerf, W A; Tsao, S C; Devuyst, O et al. (1996) NHE2 and NHE3 are human and rabbit intestinal brush-border proteins. Am J Physiol 270:G29-41
Nath, S K; Hang, C Y; Levine, S A et al. (1996) Hyperosmolarity inhibits the Na+/H+ exchanger isoforms NHE2 and NHE3: an effect opposite to that on NHE1. Am J Physiol 270:G431-41
Yun, C H; Tse, C M; Donowitz, M (1995) Chimeric Na+/H+ exchangers: an epithelial membrane-bound N-terminal domain requires an epithelial cytoplasmic C-terminal domain for regulation by protein kinases. Proc Natl Acad Sci U S A 92:10723-7
Yun, C H; Tse, C M; Nath, S K et al. (1995) Mammalian Na+/H+ exchanger gene family: structure and function studies. Am J Physiol 269:G1-11
Brant, S R; Yun, C H; Donowitz, M et al. (1995) Cloning, tissue distribution, and functional analysis of the human Na+/N+ exchanger isoform, NHE3. Am J Physiol 269:C198-206

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