Role of Pulsatile Insulin Secretion on Insulin Action

Butler, Peter Cawood

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: First Independent Research Support & Transition (FIRST) Awards (R29)
• Project #: 3R29DK044341-02S1
• Application #: 3464564
• Study Section: Metabolism Study Section (MET)
• Project Start: 1991-09-01
• Project End: 1996-08-31
• Budget Start: 1992-04-15
• Budget End: 1992-08-31
• Support Year: 2
• Fiscal Year: 1992

Institution

• Name: Mayo Clinic, Rochester
• City: Rochester
• State: MN
• Country: United States
• Zip Code: 55905

Publications

Janson, J; Ashley, R H; Harrison, D et al. (1999) The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles. Diabetes 48:491-8

Porksen, N; Munn, S; Ferguson, D et al. (1994) Coordinate pulsatile insulin secretion by chronic intraportally transplanted islets in the isolated perfused rat liver. J Clin Invest 94:219-27

O'Brien, T D; Rizza, R A; Carney, J A et al. (1994) Islet amyloidosis in a patient with chronic massive insulin resistance due to antiinsulin receptor antibodies. J Clin Endocrinol Metab 79:290-2

Usala, A L; Madigan, T; Burguera, B et al. (1992) Brief report: treatment of insulin-resistant diabetic ketoacidosis with insulin-like growth factor I in an adolescent with insulin-dependent diabetes. N Engl J Med 327:853-7