Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
7R29DK046335-06
Application #
2792980
Study Section
Molecular and Cellular Biophysics Study Section (BBCA)
Project Start
1993-05-01
Project End
1998-04-30
Budget Start
1998-02-01
Budget End
1998-04-30
Support Year
6
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Lim, Kwang Hun; Dasari, Anvesh K R; Hung, Ivan et al. (2016) Structural Changes Associated with Transthyretin Misfolding and Amyloid Formation Revealed by Solution and Solid-State NMR. Biochemistry 55:1941-4
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Cho, Younhee; Baranczak, Aleksandra; Helmke, Stephen et al. (2015) Personalized medicine approach for optimizing the dose of tafamidis to potentially ameliorate wild-type transthyretin amyloidosis (cardiomyopathy). Amyloid 22:175-80
Eisele, Yvonne S; Monteiro, Cecilia; Fearns, Colleen et al. (2015) Targeting protein aggregation for the treatment of degenerative diseases. Nat Rev Drug Discov 14:759-80
Baranczak, Aleksandra; Connelly, Stephen; Liu, Yu et al. (2014) Fluorogenic small molecules requiring reaction with a specific protein to create a fluorescent conjugate for biological imaging--what we know and what we need to learn. Biopolymers 101:484-95
Rappley, Irit; Monteiro, CecĂ­lia; Novais, Marta et al. (2014) Quantification of transthyretin kinetic stability in human plasma using subunit exchange. Biochemistry 53:1993-2006
Liu, Yu; Zhang, Xin; Tan, Yun Lei et al. (2014) De novo-designed enzymes as small-molecule-regulated fluorescence imaging tags and fluorescent reporters. J Am Chem Soc 136:13102-5
Zhang, Xin; Liu, Yu; Genereux, Joseph C et al. (2014) Heat-shock response transcriptional program enables high-yield and high-quality recombinant protein production in Escherichia coli. ACS Chem Biol 9:1945-9
Suh, Eul Hyun; Liu, Yu; Connelly, Stephen et al. (2013) Stilbene vinyl sulfonamides as fluorogenic sensors of and traceless covalent kinetic stabilizers of transthyretin that prevent amyloidogenesis. J Am Chem Soc 135:17869-80
Shoulders, Matthew D; Ryno, Lisa M; Genereux, Joseph C et al. (2013) Stress-independent activation of XBP1s and/or ATF6 reveals three functionally diverse ER proteostasis environments. Cell Rep 3:1279-92

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