Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29DK046403-04
Application #
2145610
Study Section
Medical Biochemistry Study Section (MEDB)
Project Start
1993-08-01
Project End
1998-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Emory University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
042250712
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Jumbo-Lucioni, Patricia P; Hopson, Marquise L; Hang, Darwin et al. (2013) Oxidative stress contributes to outcome severity in a Drosophila melanogaster model of classic galactosemia. Dis Model Mech 6:84-94
Daenzer, Jennifer M I; Sanders, Rebecca D; Hang, Darwin et al. (2012) UDP-galactose 4'-epimerase activities toward UDP-Gal and UDP-GalNAc play different roles in the development of Drosophila melanogaster. PLoS Genet 8:e1002721
Ryan, Emily L; DuBoff, Brian; Feany, Mel B et al. (2012) Mediators of a long-term movement abnormality in a Drosophila melanogaster model of classic galactosemia. Dis Model Mech 5:796-803
McCorvie, Thomas J; Wasilenko, Jamie; Liu, Ying et al. (2011) In vivo and in vitro function of human UDP-galactose 4'-epimerase variants. Biochimie 93:1747-54
Sanders, Rebecca D; Sefton, Jennifer M I; Moberg, Kenneth H et al. (2010) UDP-galactose 4' epimerase (GALE) is essential for development of Drosophila melanogaster. Dis Model Mech 3:628-38
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Quimby, B B; Fridovich-Keil, J L (1997) Genetic approaches to biochemical questions: insights into the functional requirements of proline 185 in the active site of human galactose-1-phosphate uridylyltransferase. SAAS Bull Biochem Biotechnol 10:43-8
Wells, L; Fridovich-Keil, J L (1996) The yeast, Saccharomyces cerevisiae, as a model system for the study of human genetic disease. SAAS Bull Biochem Biotechnol 9:83-8
Elsas, L J; Langley, S; Steele, E et al. (1995) Galactosemia: a strategy to identify new biochemical phenotypes and molecular genotypes. Am J Hum Genet 56:630-9

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