Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29DK046793-03
Application #
2146044
Study Section
Endocrinology Study Section (END)
Project Start
1994-07-01
Project End
1999-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Duke University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
Collins, S; Daniel, K W; Rohlfs, E M (1999) Depressed expression of adipocyte beta-adrenergic receptors is a common feature of congenital and diet-induced obesity in rodents. Int J Obes Relat Metab Disord 23:669-77
Soeder, K J; Snedden, S K; Cao, W et al. (1999) The beta3-adrenergic receptor activates mitogen-activated protein kinase in adipocytes through a Gi-dependent mechanism. J Biol Chem 274:12017-22
Collins, S; Daniel, K W; Petro, A E et al. (1997) Strain-specific response to beta 3-adrenergic receptor agonist treatment of diet-induced obesity in mice. Endocrinology 138:405-13
Surwit, R S; Petro, A E; Parekh, P et al. (1997) Low plasma leptin in response to dietary fat in diabetes- and obesity-prone mice. Diabetes 46:1516-20
Gettys, T W; Watson, P M; Taylor, I L et al. (1997) RU-486 (Mifepristone) ameliorates diabetes but does not correct deficient beta-adrenergic signalling in adipocytes from mature C57BL/6J-ob/ob mice. Int J Obes Relat Metab Disord 21:865-73
Collins, S; Surwit, R S (1996) Pharmacologic manipulation of ob expression in a dietary model of obesity. J Biol Chem 271:9437-40
Rohlfs, E M; Daniel, K W; Premont, R T et al. (1995) Regulation of the uncoupling protein gene (Ucp) by beta 1, beta 2, and beta 3-adrenergic receptor subtypes in immortalized brown adipose cell lines. J Biol Chem 270:10723-32
Gettys, T W; Rohlfs, E M; Prpic, V et al. (1995) Age-dependent changes in beta-adrenergic receptor subtypes and adenylyl cyclase activation in adipocytes from Fischer 344 rats. Endocrinology 136:2022-32