Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29DK046954-02
Application #
2146267
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1995-09-15
Project End
2000-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
George Washington University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Washington
State
DC
Country
United States
Zip Code
20052
Le, Man; Krilov, Lada; Meng, Jianping et al. (2006) Bile acids stimulate PKCalpha autophosphorylation and activation: role in the attenuation of prostaglandin E1-induced cAMP production in human dermal fibroblasts. Am J Physiol Gastrointest Liver Physiol 291:G275-87
Meng, Jian Ping; Ceryak, Susan; Aratsu, Zaheer et al. (2006) Biphasic regulation by bile acids of dermal fibroblast proliferation through regulation of cAMP production and COX-2 expression level. Am J Physiol Cell Physiol 291:C546-54
Matsuzaki, Yasushi; Bouscarel, Bernard; Ikegami, Tadashi et al. (2002) Selective inhibition of CYP27A1 and of chenodeoxycholic acid synthesis in cholestatic hamster liver. Biochim Biophys Acta 1588:139-48
Matsuzaki, Yasushi; Miyazaki, Teruo; Miyakawa, Syunpei et al. (2002) Decreased taurine concentration in skeletal muscles after exercise for various durations. Med Sci Sports Exerc 34:793-7
Ikegami, T; Cypess, A M; Bouscarel, B (2001) Modulation of glucagon receptor expression and response in transfected human embryonic kidney cells. Am J Physiol Cell Physiol 281:C1396-402
Ceryak, S; Bouscarel, B; Malavolti, M et al. (2000) Effect of ursodeoxycholic acid on hepatic LDL binding and uptake in dietary hypercholesterolemic hamsters. Atherosclerosis 153:59-67
Bouscarel, B; Kroll, S D; Fromm, H (1999) Signal transduction and hepatocellular bile acid transport: cross talk between bile acids and second messengers. Gastroenterology 117:433-52
Kobayashi, K; Bouscarel, B; Matsuzaki, Y et al. (1999) pH-dependent uptake of irinotecan and its active metabolite, SN-38, by intestinal cells. Int J Cancer 83:491-6
Bouscarel, B; Matsuzaki, Y; Le, M et al. (1998) Changes in G protein expression account for impaired modulation of hepatic cAMP formation after BDL. Am J Physiol 274:G1151-9
Ceryak, S; Bouscarel, B; Malavolti, M et al. (1998) Extrahepatic deposition and cytotoxicity of lithocholic acid: studies in two hamster models of hepatic failure and in cultured human fibroblasts. Hepatology 27:546-56

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