Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29DK048010-03
Application #
2148017
Study Section
Surgery and Bioengineering Study Section (SB)
Project Start
1994-05-01
Project End
1999-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02215
Bouyer, Patrice G; Tang, Xu; Weber, Christopher R et al. (2013) Capsaicin induces NKCC1 internalization and inhibits chloride secretion in colonic epithelial cells independently of TRPV1. Am J Physiol Gastrointest Liver Physiol 304:G142-56
Tang, Jun; Bouyer, Patrice; Mykoniatis, Andreas et al. (2010) Activated PKC{delta} and PKC{epsilon} inhibit epithelial chloride secretion response to cAMP via inducing internalization of the Na+-K+-2Cl- cotransporter NKCC1. J Biol Chem 285:34072-85
Mykoniatis, Andreas; Shen, Le; Fedor-Chaiken, Mary et al. (2010) Phorbol 12-myristate 13-acetate-induced endocytosis of the Na-K-2Cl cotransporter in MDCK cells is associated with a clathrin-dependent pathway. Am J Physiol Cell Physiol 298:C85-97
Hrnjez, B J; Song, J C; Prasad, M et al. (1999) Ammonia blockade of intestinal epithelial K+ conductance. Am J Physiol 277:G521-32
Matthews, J B; Smith, J A; Hrnjez, B J (1997) Effects of F-actin stabilization or disassembly on epithelial Cl- secretion and Na-K-2Cl cotransport. Am J Physiol 272:C254-62
Mayol, J M; Hrnjez, B J; Akbarali, H I et al. (1997) Ammonia effect on calcium-activated chloride secretion in T84 intestinal epithelial monolayers. Am J Physiol 273:C634-42
Tally, K J; Hrnjez, B J; Smith, J A et al. (1996) Adenosine scavenging: a novel mechanism of chloride secretory control in intestinal epithelial cells. Surgery 120:248-54
Matthews, J B; Tally, K J; Smith, J A et al. (1995) Activation of Cl secretion during chemical hypoxia by endogenous release of adenosine in intestinal epithelial monolayers. J Clin Invest 96:117-25
Matthews, J B; Tally, K J; Smith, J A (1995) Activation of intestinal Na-K-2Cl cotransport by 5'-AMP requires F-actin remodeling. Am J Surg 169:50-5;discussion 55-6
Matthews, J B; Smith, J A; Nguyen, H (1995) Modulation of intestinal chloride secretion at basolateral transport sites: opposing effects of cyclic adenosine monophosphate and phorbol ester. Surgery 118:147-52;discussion 152-3

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