Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
1R29DK049845-01A1
Application #
2150778
Study Section
Biochemical Endocrinology Study Section (BCE)
Project Start
1996-06-01
Project End
2001-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Children's Hosp Pittsburgh/Upmc Health Sys
Department
Type
DUNS #
044304145
City
Pittsburgh
State
PA
Country
United States
Zip Code
15224
Lu, Chunxia; Kumar, P Anil; Sun, Jinhong et al. (2013) Targeted deletion of growth hormone (GH) receptor in macrophage reveals novel osteopontin-mediated effects of GH on glucose homeostasis and insulin sensitivity in diet-induced obesity. J Biol Chem 288:15725-35
Kumar, P Anil; Brosius 3rd, Frank C; Menon, Ram K (2011) The glomerular podocyte as a target of growth hormone action: implications for the pathogenesis of diabetic nephropathy. Curr Diabetes Rev 7:50-5
Sun, Jinhong; Kumar, P Anil; Thimmarayappa, Jamuna et al. (2011) Esterase 1 is a novel transcriptional repressor of growth hormone receptor gene expression: a unique noncatalytic role for a carboxyesterase protein. Mol Endocrinol 25:1351-63
Lu, Chunxia; Kumar, P Anil; Fan, Yong et al. (2010) A novel effect of growth hormone on macrophage modulates macrophage-dependent adipocyte differentiation. Endocrinology 151:2189-99
Kumar, P Anil; Kotlyarevska, Kateryna; Dejkhmaron, Prapai et al. (2010) Growth hormone (GH)-dependent expression of a natural antisense transcript induces zinc finger E-box-binding homeobox 2 (ZEB2) in the glomerular podocyte: a novel action of gh with implications for the pathogenesis of diabetic nephropathy. J Biol Chem 285:31148-56
Thomas, Inas H; Saini, Natinder K; Adhikari, Amita et al. (2009) Neonatal diabetes mellitus with pancreatic agenesis in an infant with homozygous IPF-1 Pro63fsX60 mutation. Pediatr Diabetes 10:492-6
Menon, R K; Shaufl, A; Yu, J H et al. (2001) Identification and characterization of a novel transcript of the murine growth hormone receptor gene exhibiting development- and tissue-specific expression. Mol Cell Endocrinol 172:135-46
Yu, J H; Schwartzbauer, G; Kazlman, A et al. (1999) Role of the Sp family of transcription factors in the ontogeny of growth hormone receptor gene expression. J Biol Chem 274:34327-36
Schwartzbauer, G; Yu, J H; Cheng, H et al. (1998) Transcription factor MSY-1 regulates expression of the murine growth hormone receptor gene. J Biol Chem 273:24760-9
Schwartzbauer, G; Menon, R K (1998) Regulation of growth hormone receptor gene expression. Mol Genet Metab 63:243-53

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