This application focuses on assembly of regulatory nucleoprotein complex at cAMP-regulated enhancer (CRE). The investigation proposes studies on: 1) regulation of CREB dimerization by accessory proteins initially define role of dimerization in DNA binding and the role of HIV-1 (Tax) or GroEL; 2) the dynamics of coactivator proteins association with phosphorylated forms of CREB; and 3) allosteric modulation of CREB and CBP (a coactivator).

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29DK051732-04
Application #
2905924
Study Section
Biological Sciences 2 (BIOL)
Program Officer
Margolis, Ronald N
Project Start
1996-08-22
Project End
2001-06-30
Budget Start
1999-07-01
Budget End
2000-06-30
Support Year
4
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Oregon Health and Science University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
009584210
City
Portland
State
OR
Country
United States
Zip Code
97239