Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29ES004302-05
Application #
3465147
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1988-09-01
Project End
1994-08-31
Budget Start
1992-09-01
Budget End
1994-08-31
Support Year
5
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of Hawaii
Department
Type
Schools of Medicine
DUNS #
121911077
City
Honolulu
State
HI
Country
United States
Zip Code
96822
Cooney, R V; Franke, A A; Hankin, J H et al. (1995) Seasonal variations in plasma micronutrients and antioxidants. Cancer Epidemiol Biomarkers Prev 4:207-15
Cooney, R V; Harwood, P J; Franke, A A et al. (1995) Products of gamma-tocopherol reaction with NO2 and their formation in rat insulinoma (RINm5F) cells. Free Radic Biol Med 19:259-69
Cooney, R V; Harwood, P J; Custer, L J et al. (1994) Light-mediated conversion of nitrogen dioxide to nitric oxide by carotenoids. Environ Health Perspect 102:460-2
Franke, A A; Harwood, P J; Shimamoto, T et al. (1994) Effects of micronutrients and antioxidants on lipid peroxidation in human plasma and in cell culture. Cancer Lett 79:17-26
Cooney, R V; Franke, A A; Harwood, P J et al. (1993) Gamma-tocopherol detoxification of nitrogen dioxide: superiority to alpha-tocopherol. Proc Natl Acad Sci U S A 90:1771-5
Cooney, R V; Kappock 4th, T J; Pung, A et al. (1993) Solubilization, cellular uptake, and activity of beta-carotene and other carotenoids as inhibitors of neoplastic transformation in cultured cells. Methods Enzymol 214:55-68
Mordan, L J; Burnett, T S; Zhang, L X et al. (1993) Inhibitors of endogenous nitrogen oxide formation block the promotion of neoplastic transformation in C3H 10T1/2 fibroblasts. Carcinogenesis 14:1555-9
Arroyo, P L; Hatch-Pigott, V; Mower, H F et al. (1992) Mutagenicity of nitric oxide and its inhibition by antioxidants. Mutat Res 281:193-202
Cooney, R V; Pung, A; Harwood, P J et al. (1992) Inhibition of cellular transformation by triphenylmethane: a novel chemopreventive agent. Carcinogenesis 13:1107-12
Zhang, L X; Cooney, R V; Bertram, J S (1991) Carotenoids enhance gap junctional communication and inhibit lipid peroxidation in C3H/10T1/2 cells: relationship to their cancer chemopreventive action. Carcinogenesis 12:2109-14