Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29ES006016-05
Application #
2154848
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1992-06-01
Project End
1998-05-31
Budget Start
1996-06-01
Budget End
1998-05-31
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Texas A&M University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
City
College Station
State
TX
Country
United States
Zip Code
77845
Thompson, D C; Perera, K; London, R (2000) Spontaneous hydrolysis of 4-trifluoromethylphenol to a quinone methide and subsequent protein alkylation. Chem Biol Interact 126:14-Jan
Thompson, D C; Barhoumi, R; Burghardt, R C (1998) Comparative toxicity of eugenol and its quinone methide metabolite in cultured liver cells using kinetic fluorescence bioassays. Toxicol Appl Pharmacol 149:55-63
Reed, M; Thompson, D C (1997) Immunochemical visualization and identification of rat liver proteins adducted by 2,6-di-tert-butyl-4-methylphenol (BHT). Chem Res Toxicol 10:1109-17
Thompson, D C; Perera, K; London, R (1996) Metabolism and toxicity of 4-hydroxyphenylacetone in rat liver slices: comparison with acetaminophen. Drug Metab Dispos 24:866-71
Thompson, D C; Perera, K; London, R (1996) Studies on the mechanism of hepatotoxicity of 4-methylphenol (p-cresol): effects of deuterium labeling and ring substitution. Chem Biol Interact 101:1-11
Thompson, D C; Perera, K; London, R (1995) Quinone methide formation from para isomers of methylphenol (cresol), ethylphenol, and isopropylphenol: relationship to toxicity. Chem Res Toxicol 8:55-60
Thompson, D C; Perera, K; Krol, E S et al. (1995) o-Methoxy-4-alkylphenols that form quinone methides of intermediate reactivity are the most toxic in rat liver slices. Chem Res Toxicol 8:323-7
Thompson, D C; Perera, K (1995) Inhibition of mitochondrial respiration by a para-quinone methide. Biochem Biophys Res Commun 209:6-11
Thompson, D C; Reed, M (1995) Inhibition of NAD(H)/NADP(H)--requiring enzymes by aurintricarboxylic acid. Toxicol Lett 81:141-9
Thompson, D C; Perera, K; Fisher, R et al. (1994) Cresol isomers: comparison of toxic potency in rat liver slices. Toxicol Appl Pharmacol 125:51-8

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