Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
3R29EY007961-04S1
Application #
3465682
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1990-07-01
Project End
1993-12-31
Budget Start
1991-01-01
Budget End
1991-12-31
Support Year
4
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Beltran, William A; Cideciyan, Artur V; Lewin, Alfred S et al. (2014) Gene augmentation for X-linked retinitis pigmentosa caused by mutations in RPGR. Cold Spring Harb Perspect Med 5:a017392
Beltran, William A; Cideciyan, Artur V; Lewin, Alfred S et al. (2012) Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa. Proc Natl Acad Sci U S A 109:2132-7
Branham, Kari; Othman, Mohammad; Brumm, Matthew et al. (2012) Mutations in RPGR and RP2 account for 15% of males with simplex retinal degenerative disease. Invest Ophthalmol Vis Sci 53:8232-7
Chakarova, Christina F; Khanna, Hemant; Shah, Amna Z et al. (2011) TOPORS, implicated in retinal degeneration, is a cilia-centrosomal protein. Hum Mol Genet 20:975-87
Murga-Zamalloa, Carlos A; Ghosh, Amiya K; Patil, Suresh B et al. (2011) Accumulation of the Raf-1 kinase inhibitory protein (Rkip) is associated with Cep290-mediated photoreceptor degeneration in ciliopathies. J Biol Chem 286:28276-86
O'Toole, John F; Liu, Yangjian; Davis, Erica E et al. (2010) Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy. J Clin Invest 120:791-802
Wu, D M; Khanna, H; Atmaca-Sonmez, P et al. (2010) Long-term follow-up of a family with dominant X-linked retinitis pigmentosa. Eye (Lond) 24:764-74
Patzke, Sebastian; Redick, Sambra; Warsame, Abdirashid et al. (2010) CSPP is a ciliary protein interacting with Nephrocystin 8 and required for cilia formation. Mol Biol Cell 21:2555-67
Hurd, Toby; Zhou, Weibin; Jenkins, Paul et al. (2010) The retinitis pigmentosa protein RP2 interacts with polycystin 2 and regulates cilia-mediated vertebrate development. Hum Mol Genet 19:4330-44
Patil, Suresh B; Verma, Rakesh; Venkatareddy, Madhusudan et al. (2010) Expression and localization of the ciliary disease protein retinitis pigmentosa GTPase regulator in mammalian kidney. Kidney Int 78:622-3

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