Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29EY010827-02
Application #
2164972
Study Section
Visual Sciences C Study Section (VISC)
Project Start
1995-09-01
Project End
2000-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Joslin Diabetes Center
Department
Type
DUNS #
071723084
City
Boston
State
MA
Country
United States
Zip Code
02215

  Publications

Suzuma, Kiyoshi; Takahara, Noriko; Suzuma, Izumi et al. (2002) Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization. Proc Natl Acad Sci U S A 99:721-6
Suzuma, Izumi; Suzuma, Kiyoshi; Ueki, Kohjiro et al. (2002) Stretch-induced retinal vascular endothelial growth factor expression is mediated by phosphatidylinositol 3-kinase and protein kinase C (PKC)-zeta but not by stretch-induced ERK1/2, Akt, Ras, or classical/novel PKC pathways. J Biol Chem 277:1047-57
Suzuma, I; Hata, Y; Clermont, A et al. (2001) Cyclic stretch and hypertension induce retinal expression of vascular endothelial growth factor and vascular endothelial growth factor receptor-2: potential mechanisms for exacerbation of diabetic retinopathy by hypertension. Diabetes 50:444-54
Hata, Y; Clermont, A; Yamauchi, T et al. (2000) Retinal expression, regulation, and functional bioactivity of prostacyclin-stimulating factor. J Clin Invest 106:541-50
Cai, W; Rook, S L; Jiang, Z Y et al. (2000) Mechanisms of hepatocyte growth factor-induced retinal endothelial cell migration and growth. Invest Ophthalmol Vis Sci 41:1885-93
Hata, Y; Rook, S L; Aiello, L P (1999) Basic fibroblast growth factor induces expression of VEGF receptor KDR through a protein kinase C and p44/p42 mitogen-activated protein kinase-dependent pathway. Diabetes 48:1145-55
Schuppin, G T; Pons, S; Hugl, S et al. (1998) A specific increased expression of insulin receptor substrate 2 in pancreatic beta-cell lines is involved in mediating serum-stimulated beta-cell growth. Diabetes 47:1074-85
Takagi, H; King, G L; Aiello, L P (1998) Hypoxia upregulates glucose transport activity through an adenosine-mediated increase of GLUT1 expression in retinal capillary endothelial cells. Diabetes 47:1480-8
Hata, Y; Duh, E; Zhang, K et al. (1998) Transcription factors Sp1 and Sp3 alter vascular endothelial growth factor receptor expression through a novel recognition sequence. J Biol Chem 273:19294-303
Vasir, B; Aiello, L P; Yoon, K H et al. (1998) Hypoxia induces vascular endothelial growth factor gene and protein expression in cultured rat islet cells. Diabetes 47:1894-903

Showing the most recent 10 out of 17 publications