By using electrical stimulation to bypass neurons which have become non-functional, implanted neural prostheses such as the cochlear implant have rehabilitated patients for whom there is no other treatment. The applicant proposes that a similar approach could benefit a subset of patients blind from retinitis pigmentosa and age-related macular degeneration, two leading causes of blindness. The results to date have supported this approach and show that vision compatible with mobility and large print reading is possible. The next critical step is to determine the maximum resolution affordable by such an approach. In this proposal, the applicant delineates key experiments necessary to achieve this goal.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29EY011888-03
Application #
2888580
Study Section
Visual Sciences C Study Section (VISC)
Project Start
1997-09-30
Project End
2002-09-29
Budget Start
1999-09-30
Budget End
2000-09-29
Support Year
3
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Behrend, Matthew R; Ahuja, Ashish K; Humayun, Mark S et al. (2011) Resolution of the epiretinal prosthesis is not limited by electrode size. IEEE Trans Neural Syst Rehabil Eng 19:436-42
Behrend, Matthew R; Ahuja, Ashish K; Humayun, Mark S et al. (2009) Selective labeling of retinal ganglion cells with calcium indicators by retrograde loading in vitro. J Neurosci Methods 179:166-72
Humayun, Mark S; Dorn, Jessy D; Ahuja, Ashish K et al. (2009) Preliminary 6 month results from the Argus II epiretinal prosthesis feasibility study. Conf Proc IEEE Eng Med Biol Soc 2009:4566-8
Majji, A B; Humayun, M S; Weiland, J D et al. (1999) Long-term histological and electrophysiological results of an inactive epiretinal electrode array implantation in dogs. Invest Ophthalmol Vis Sci 40:2073-81