Structure, Function, & Dynamics of P-450 Cytochromes

Black, Shaun

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of General Medical Sciences (NIGMS)
• Type: First Independent Research Support & Transition (FIRST) Awards (R29)
• Project #: 5R29GM038261-05
• Application #: 3466230
• Study Section: Physical Biochemistry Study Section (PB)
• Project Start: 1988-02-01
• Project End: 1992-07-31
• Budget Start: 1992-02-01
• Budget End: 1992-07-31
• Support Year: 5
• Fiscal Year: 1992

Institution

• Name: Ohio State University
• Type: Schools of Pharmacy
• DUNS #: 098987217
• City: Columbus
• State: OH
• Country: United States
• Zip Code: 43210

Publications

Black, S D; Martin, S T (1994) Simplified loading of a multiple-channel immunoblot apparatus. Biotechniques 16:202-4

Black, S D; Martin, S T; Smith, C A (1994) Membrane topology of liver microsomal cytochrome P450 2B4 determined via monoclonal antibodies directed to the halt-transfer signal. Biochemistry 33:6945-51

Black, S D; Linger, M H; Freck, L C et al. (1994) Affinity isolation and characterization of cytochrome P450 102 (BM-3) from barbiturate-induced Bacillus megaterium. Arch Biochem Biophys 310:126-33

Black, S D; Martin, S T (1994) Evidence for conformational dynamics and molecular aggregation in cytochrome P450 102 (BM-3). Biochemistry 33:12056-62

Wrighton, S A; Vandenbranden, M; Becker, G W et al. (1992) Two monoclonal antibodies recognizing different epitopes on rat cytochrome IIB1 react with human IIE1. Mol Pharmacol 41:76-82

Black, S D (1992) Membrane topology of the mammalian P450 cytochromes. FASEB J 6:680-5

Brown, C A; Black, S D (1989) Membrane topology of mammalian cytochromes P-450 from liver endoplasmic reticulum. Determination by trypsinolysis of phenobarbital-treated microsomes. J Biol Chem 264:4442-9