The objectives of this research program are to study the sequence of cellular and molecular events initiated by antigen receptor perturbation and which culminate in T cell activation. These objectives will be accomplished by the techniques of differential nucleic acid hybridization in order to isolate genes that are transcriptionally active as a result of antigen receptor-induced activation. The development of cDNA probes from these genes will allow detailed analysis of T cell activation kinetics and stimulus-response coupling in this critical immunoregulatory cell as well as the identification of previously uncharacterized lymphokines. Aberrant and inappropriate T cell activation has a central role in the etiology of a variety of autoimmune, neoplastic, and hematologic disorders. Delineation of the mechanisms and consequences of immune T cell recognition of antigen will permit the development of novel strategies for specific immunotherapy based on a more complete understanding of the T cell activation sequence.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29GM038970-05
Application #
3466576
Study Section
Immunobiology Study Section (IMB)
Project Start
1988-02-01
Project End
1992-06-30
Budget Start
1990-07-01
Budget End
1991-06-30
Support Year
5
Fiscal Year
1990
Total Cost
Indirect Cost
Name
St. Jude Children's Research Hospital
Department
Type
DUNS #
067717892
City
Memphis
State
TN
Country
United States
Zip Code
38105
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