The construction of new carbon-carbon bonds is central to the synthesis of the complex molecules often found to display useful or interesting biochemical or physiological activity. Organotransition metal complexes continue to offer versatile new approaches to bond formation. Metallacyclobutenes react with unsaturated organic substrates such as carbonyl compounds, nitriles, and sulfoxides, yielding organometallic complexes which may be transformed into a wide variety of important heterocyclic organic molecules. The generality and functional group tolerances of these transformations will be explored. Further synthetic applications will be achieved through the synthesis of a series of new metallacyclobutenes, in which systematic variation of the transition metal and of its supporting ligands will permit both coarse and fine tuning of metallacycle reactivity and substrate specificity.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29GM039494-03
Application #
3466789
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1989-07-01
Project End
1993-06-30
Budget Start
1990-07-01
Budget End
1991-06-30
Support Year
3
Fiscal Year
1990
Total Cost
Indirect Cost
Name
University of Oregon
Department
Type
Schools of Arts and Sciences
DUNS #
948117312
City
Eugene
State
OR
Country
United States
Zip Code
97403