Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
7R29GM042957-05
Application #
3467848
Study Section
Pharmacology A Study Section (PHRA)
Project Start
1989-07-01
Project End
1994-06-30
Budget Start
1993-02-01
Budget End
1993-06-30
Support Year
5
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Pharmacia and Upjohn, Inc.
Department
Type
DUNS #
City
Kalamazoo
State
MI
Country
United States
Zip Code
49001
Jaeschke, Hartmut (2002) Neutrophil-mediated tissue injury in alcoholic hepatitis. Alcohol 27:23-7
Jaeschke, H; Smith, C W; Clemens, M G et al. (1996) Mechanisms of inflammatory liver injury: adhesion molecules and cytotoxicity of neutrophils. Toxicol Appl Pharmacol 139:213-26
Liu, P; McGuire, G M; Fisher, M A et al. (1995) Activation of Kupffer cells and neutrophils for reactive oxygen formation is responsible for endotoxin-enhanced liver injury after hepatic ischemia. Shock 3:56-62
Wang, Y; Mathews, W R; Guido, D M et al. (1995) Inhibition of nitric oxide synthesis aggravates reperfusion injury after hepatic ischemia and endotoxemia. Shock 4:282-8
Essani, N A; Fisher, M A; Farhood, A et al. (1995) Cytokine-induced upregulation of hepatic intercellular adhesion molecule-1 messenger RNA expression and its role in the pathophysiology of murine endotoxin shock and acute liver failure. Hepatology 21:1632-9
Mathews, W R; Guido, D M; Fisher, M A et al. (1994) Lipid peroxidation as molecular mechanism of liver cell injury during reperfusion after ischemia. Free Radic Biol Med 16:763-70
Liu, P; Vonderfecht, S L; McGuire, G M et al. (1994) The 21-aminosteroid tirilazad mesylate protects against endotoxin shock and acute liver failure in rats. J Pharmacol Exp Ther 271:438-45
Liu, P; Fisher, M A; Farhood, A et al. (1994) Beneficial effects of extracellular glutathione against endotoxin-induced liver injury during ischemia and reperfusion. Circ Shock 43:64-70
Liu, P; Vonderfecht, S L; Fisher, M A et al. (1994) Priming of phagocytes for reactive oxygen production during hepatic ischemia-reperfusion potentiates the susceptibility for endotoxin-induced liver injury. Circ Shock 43:9-17
Jaeschke, H; Farhood, A; Smith, C W (1994) Contribution of complement-stimulated hepatic macrophages and neutrophils to endotoxin-induced liver injury in rats. Hepatology 19:973-9

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