Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29GM047297-02
Application #
2184717
Study Section
Physical Biochemistry Study Section (PB)
Project Start
1995-05-01
Project End
1996-10-31
Budget Start
1996-05-01
Budget End
1996-10-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Biochemistry
Type
Other Domestic Higher Education
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Hengge, Alvan C (2015) Kinetic isotope effects in the characterization of catalysis by protein tyrosine phosphatases. Biochim Biophys Acta 1854:1768-75
Kuznetsov, Vyacheslav I; Hengge, Alvan C (2013) New functional aspects of the atypical protein tyrosine phosphatase VHZ. Biochemistry 52:8012-25
Whittier, Sean K; Hengge, Alvan C; Loria, J Patrick (2013) Conformational motions regulate phosphoryl transfer in related protein tyrosine phosphatases. Science 341:899-903
Brandão, Tiago A S; Johnson, Sean J; Hengge, Alvan C (2012) The molecular details of WPD-loop movement differ in the protein-tyrosine phosphatases YopH and PTP1B. Arch Biochem Biophys 525:53-9
Kuznetsov, Vyacheslav I; Alexandrova, Anastassia N; Hengge, Alvan C (2012) Metavanadate at the active site of the phosphatase VHZ. J Am Chem Soc 134:14298-301
Kuznetsov, Vyacheslav I; Hengge, Alvan C; Johnson, Sean J (2012) New aspects of the phosphatase VHZ revealed by a high-resolution structure with vanadate and substrate screening. Biochemistry 51:9869-79
Brandão, Tiago A S; Hengge, Alvan C; Johnson, Sean J (2010) Insights into the reaction of protein-tyrosine phosphatase 1B: crystal structures for transition state analogs of both catalytic steps. J Biol Chem 285:15874-83
Miti?, Natasa; Hadler, Kieran S; Gahan, Lawrence R et al. (2010) The divalent metal ion in the active site of uteroferrin modulates substrate binding and catalysis. J Am Chem Soc 132:7049-54
Brandão, Tiago A S; Robinson, Howard; Johnson, Sean J et al. (2009) Impaired acid catalysis by mutation of a protein loop hinge residue in a YopH mutant revealed by crystal structures. J Am Chem Soc 131:778-86
Smith, Gregory K; Ke, Zhihong; Hengge, Alvan C et al. (2009) Active-site dynamics of SpvC virulence factor from Salmonella typhimurium and density functional theory study of phosphothreonine lyase catalysis. J Phys Chem B 113:15327-33

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