Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29GM047480-05
Application #
2184939
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1992-05-01
Project End
1997-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Boston College
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
045896339
City
Chestnut Hill
State
MA
Country
United States
Zip Code
02467
Shi, Ying; Hoveyda, Amir H (2016) Catalytic SN2'- and Enantioselective Allylic Substitution with a Diborylmethane Reagent and Application in Synthesis. Angew Chem Int Ed Engl 55:3455-8
Shi, Ying; Jung, Byunghyuck; Torker, Sebastian et al. (2015) N-Heterocyclic Carbene-Copper-Catalyzed Group-, Site-, and Enantioselective Allylic Substitution with a Readily Accessible Propargyl(pinacolato)boron Reagent: Utility in Stereoselective Synthesis and Mechanistic Attributes. J Am Chem Soc 137:8948-64
McGrath, Kevin P; Hoveyda, Amir H (2014) A multicomponent Ni-, Zr-, and Cu-catalyzed strategy for enantioselective synthesis of alkenyl-substituted quaternary carbons. Angew Chem Int Ed Engl 53:1910-4
Jang, Hwanjong; Jung, Byunghyuck; Hoveyda, Amir H (2014) Catalytic enantioselective protoboration of disubstituted allenes. Access to alkenylboron compounds in high enantiomeric purity. Org Lett 16:4658-61
Gao, Fang; Carr, James L; Hoveyda, Amir H (2014) A broadly applicable NHC-Cu-catalyzed approach for efficient, site-, and enantioselective coupling of readily accessible (pinacolato)alkenylboron compounds to allylic phosphates and applications to natural product synthesis. J Am Chem Soc 136:2149-61
Meng, Fanke; McGrath, Kevin P; Hoveyda, Amir H (2014) Multifunctional organoboron compounds for scalable natural product synthesis. Nature 513:367-74
Meng, Fanke; Haeffner, Fredrik; Hoveyda, Amir H (2014) Diastereo- and enantioselective reactions of bis(pinacolato)diboron, 1,3-enynes, and aldehydes catalyzed by an easily accessible bisphosphine-Cu complex. J Am Chem Soc 136:11304-7
Hoveyda, Amir H (2014) Evolution of catalytic stereoselective olefin metathesis: from ancillary transformation to purveyor of stereochemical identity. J Org Chem 79:4763-92
Dabrowski, Jennifer A; Haeffner, Fredrik; Hoveyda, Amir H (2013) Combining NHC-Cu and Brønsted base catalysis: enantioselective allylic substitution/conjugate additions with alkynylaluminum reagents and stereospecific isomerization of the products to trisubstituted allenes. Angew Chem Int Ed Engl 52:7694-9
Meng, Fanke; Jung, Byunghyuck; Haeffner, Fredrik et al. (2013) NHC-Cu-catalyzed protoboration of monosubstituted allenes. Ligand-controlled site selectivity, application to synthesis and mechanism. Org Lett 15:1414-7

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