Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29GM048877-04
Application #
2186389
Study Section
Physical Biochemistry Study Section (PB)
Project Start
1993-08-01
Project End
1998-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Smithrud, D B; Benkovic, P A; Benkovic, S J et al. (2000) Cyclic peptide formation catalyzed by an antibody ligase. Proc Natl Acad Sci U S A 97:1953-8
Thayer, M M; Olender, E H; Arvai, A S et al. (1999) Structural basis for amide hydrolysis catalyzed by the 43C9 antibody. J Mol Biol 291:329-45
Pellequer, J L; Chen, S w; Roberts, V A et al. (1999) Unraveling the effect of changes in conformation and compactness at the antibody V(L)-V(H) interface upon antigen binding. J Mol Recognit 12:267-75
Wiens, G D; Roberts, V A; Whitcomb, E A et al. (1998) Harmful somatic mutations: lessons from the dark side. Immunol Rev 162:197-209
Brown, M; Rittenburg, M B; Chen, C et al. (1996) Tolerance of single, but not multiple, amino acid replacements in antibody VH CDR 2: a means of minimizing B cell wastage from somatic hypermutation? J Immunol 156:3285-91
Pulito, V L; Roberts, V A; Adair, J R et al. (1996) Humanization and molecular modeling of the anti-CD4 monoclonal antibody, OKT4A. J Immunol 156:2840-50
Chen, C; Roberts, V A; Stevens, S et al. (1995) Enhancement and destruction of antibody function by somatic mutation: unequal occurrence is controlled by V gene combinatorial associations. EMBO J 14:2784-94
Roberts, V A; Getzoff, E D (1995) Metalloantibody design. FASEB J 9:94-100
Friedman, A R; Roberts, V A; Tainer, J A (1994) Predicting molecular interactions and inducible complementarity: fragment docking of Fab-peptide complexes. Proteins 20:15-24