Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29GM049164-04
Application #
2186712
Study Section
Physiological Chemistry Study Section (PC)
Project Start
1993-04-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Indiana University-Purdue University at Indianapolis
Department
Biochemistry
Type
Schools of Medicine
DUNS #
005436803
City
Indianapolis
State
IN
Country
United States
Zip Code
46202

  Publications

Young, Sara K; Palam, Lakshmi Reddy; Wu, Cheng et al. (2016) Ribosome Elongation Stall Directs Gene-specific Translation in the Integrated Stress Response. J Biol Chem 291:6546-58
Wilson, Gabriel J; Lennox, Brittany A; She, Pengxiang et al. (2015) GCN2 is required to increase fibroblast growth factor 21 and maintain hepatic triglyceride homeostasis during asparaginase treatment. Am J Physiol Endocrinol Metab 308:E283-93
Willy, Jeffrey A; Young, Sara K; Stevens, James L et al. (2015) CHOP links endoplasmic reticulum stress to NF-?B activation in the pathogenesis of nonalcoholic steatohepatitis. Mol Biol Cell 26:2190-204
Collier, Ann E; Wek, Ronald C; Spandau, Dan F (2015) Translational Repression Protects Human Keratinocytes from UVB-Induced Apoptosis through a Discordant eIF2 Kinase Stress Response. J Invest Dermatol 135:2502-2511
Young, Sara K; Willy, Jeffrey A; Wu, Cheng et al. (2015) Ribosome Reinitiation Directs Gene-specific Translation and Regulates the Integrated Stress Response. J Biol Chem 290:28257-71
He, Hongzhen; Singh, Isha; Wek, Sheree A et al. (2014) Crystal structures of GCN2 protein kinase C-terminal domains suggest regulatory differences in yeast and mammals. J Biol Chem 289:15023-34
Konrad, Christian; Wek, Ronald C; Sullivan Jr, William J (2014) GCN2-like eIF2? kinase manages the amino acid starvation response in Toxoplasma gondii. Int J Parasitol 44:139-46
Baird, Thomas D; Palam, Lakshmi Reddy; Fusakio, Michael E et al. (2014) Selective mRNA translation during eIF2 phosphorylation induces expression of IBTK?. Mol Biol Cell 25:1686-97
Teske, Brian F; Fusakio, Michael E; Zhou, Donghui et al. (2013) CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis. Mol Biol Cell 24:2477-90
She, Pengxiang; Bunpo, Piyawan; Cundiff, Judy K et al. (2013) General control nonderepressible 2 (GCN2) kinase protects oligodendrocytes and white matter during branched-chain amino acid deficiency in mice. J Biol Chem 288:31250-60

Showing the most recent 10 out of 22 publications