Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29GM049871-03
Application #
2187428
Study Section
Metallobiochemistry Study Section (BMT)
Project Start
1994-04-01
Project End
1999-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Duke University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
Wisz, M S; Garrett, C Z; Hellinga, H W (1998) Construction of a family of Cys2His2 zinc binding sites in the hydrophobic core of thioredoxin by structure-based design. Biochemistry 37:8269-77
Benson, D E; Wisz, M S; Liu, W et al. (1998) Construction of a novel redox protein by rational design: conversion of a disulfide bridge into a mononuclear iron-sulfur center. Biochemistry 37:7070-6
Hellinga, H W (1998) The construction of metal centers in proteins by rational design. Fold Des 3:R1-8
Coldren, C D; Hellinga, H W; Caradonna, J P (1997) The rational design and construction of a cuboidal iron-sulfur protein. Proc Natl Acad Sci U S A 94:6635-40
Pinto, A L; Hellinga, H W; Caradonna, J P (1997) Construction of a catalytically active iron superoxide dismutase by rational protein design. Proc Natl Acad Sci U S A 94:5562-7