Brain Ion Channel Regulation in Anoxia and Anesthesia

Bickler, Philip E.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of General Medical Sciences (NIGMS)
• Type: First Independent Research Support & Transition (FIRST) Awards (R29)
• Project #: 5R29GM052212-03
• Application #: 2191151
• Study Section: Surgery, Anesthesiology and Trauma Study Section (SAT)
• Project Start: 1994-08-01
• Project End: 1999-07-31
• Budget Start: 1996-08-01
• Budget End: 1997-07-31
• Support Year: 3
• Fiscal Year: 1996

Institution

• Name: University of California San Francisco
• Department: Anesthesiology
• Type: Schools of Medicine
• DUNS #: 073133571
• City: San Francisco
• State: CA
• Country: United States
• Zip Code: 94143

Publications

Bickler, Philip E; Fahlman, Christian S; Gray, Jonathan J (2010) Hypoxic preconditioning failure in aging hippocampal neurons: impaired gene expression and rescue with intracellular calcium chelation. J Neurosci Res 88:3520-9

Bickler, P E; Fahlman, C S; Gray, J et al. (2009) Inositol 1,4,5-triphosphate receptors and NAD(P)H mediate Ca2+ signaling required for hypoxic preconditioning of hippocampal neurons. Neuroscience 160:51-60

Liniger, R; Popovic, R; Sullivan, B et al. (2001) Effects of neuroprotective cocktails on hippocampal neuron death in an in vitro model of cerebral ischemia. J Neurosurg Anesthesiol 13:19-25

Bickler, P E (1998) Reduction of NMDA receptor activity in cerebrocortex of turtles (Chrysemys picta) during 6 wk of anoxia. Am J Physiol 275:R86-91

Bickler, P E; Hansen, B M (1998) Hypoxia-tolerant neonatal CA1 neurons: relationship of survival to evoked glutamate release and glutamate receptor-mediated calcium changes in hippocampal slices. Brain Res Dev Brain Res 106:57-69