This project involves the application of two facile cyclization systems for the development of redox-sensitive protecting groups for organic synthesis. The feasibility of applying such facile cyclization systems in peptide synthesis will also be studied. Because the facile cyclization systems are cleaved under mild reductive conditions, they can be selectively removed without affecting other functional groups commonly seen in organic compounds and peptides. Therefore, this provides a protecting strategy, which is orthogonal to other methods available. Efforts will he focused on testing the practical feasibility of applying these two facile cyclization systems in organic and peptide syntheses.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29GM052515-04
Application #
2459612
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1995-04-01
Project End
2000-07-30
Budget Start
1997-08-01
Budget End
1998-07-31
Support Year
4
Fiscal Year
1997
Total Cost
Indirect Cost
Name
North Carolina State University Raleigh
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
City
Raleigh
State
NC
Country
United States
Zip Code
27695