Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
1R29GM053481-01
Application #
2192846
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Project Start
1996-03-01
Project End
2001-02-28
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Raines, D E; Claycomb, R J; Scheller, M et al. (2001) Nonhalogenated alkane anesthetics fail to potentiate agonist actions on two ligand-gated ion channels. Anesthesiology 95:470-7
Raines, D E; Zachariah, V T (2000) Isoflurane increases the apparent agonist affinity of the nicotinic acetylcholine receptor by reducing the microscopic agonist dissociation constant. Anesthesiology 92:775-85
Raines, D E; Zachariah, V T (1999) Isoflurane increases the apparent agonist affinity of the nicotinic acetylcholine receptor. Anesthesiology 90:135-46
Raines, D E; Zachariah, V T (1999) The alkyl chain dependence of the effect of normal alcohols on agonist-induced nicotinic acetylcholine receptor desensitization kinetics. Anesthesiology 91:222-30
Forman, S A; Raines, D E (1998) Nonanesthetic volatile drugs obey the Meyer-Overton correlation in two molecular protein site models. Anesthesiology 88:1535-48
Raines, D E (1998) Conformational transitions of the nicotinic acetylcholine receptor as a model for anesthetic actions on ligand-gated ion channels: single and sequential mixing stopped-flow fluorescence studies. Toxicol Lett 100-101:163-8
Raines, D E; Krishnan, N S (1998) Agonist binding and affinity state transitions in reconstituted nicotinic acetylcholine receptors revealed by single and sequential mixing stopped-flow fluorescence spectroscopies. Biochim Biophys Acta 1374:83-93
Raines, D E; Krishnan, N S (1998) Transient low-affinity agonist binding to Torpedo postsynaptic membranes resolved by using sequential mixing stopped-flow fluorescence spectroscopy. Biochemistry 37:956-64
Raines, D E; McClure, K B (1997) Halothane interactions with nicotinic acetylcholine receptor membranes. Steady-state and kinetic studies of intrinsic fluorescence quenching. Anesthesiology 86:476-86