This is a proposal to find new components of a plant pathogen-response signal transduction pathway. As such, it is in the general area of eukaryotic signal transduction, and among eukaryotic signal transduction pathways the gene-for-gene plant resistance pathway is unique and just beginning to be understood. The background is that plant pathogens, in this case the bacterium Pseudomonas syringae carrying the avrRpt2 avirulence gene, induce a plant response that depends on the specific avirulence gene and on a plant resistance gene. The Arabidopsis resistance gene that responds to avrRpt2 is RPS2; when active it causes plants to have a hypersensitive response that limits pathogen growth. Recent cloning of RPS2 by two groups (one including the PI) shows it to code a protein with a leucine zipper near the amino terminus, a nucleotide triphosphate binding loop and near the carboxy- terminal end a series of leucine rich repeats, of the type found in receptors, and in other proteins that are activated by protein- protein contacts, such as yeast adenylate cyclase.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29GM053595-03
Application #
2668513
Study Section
Genetics Study Section (GEN)
Project Start
1996-03-01
Project End
2001-02-28
Budget Start
1998-03-01
Budget End
1999-02-28
Support Year
3
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Illinois Urbana-Champaign
Department
Miscellaneous
Type
Schools of Earth Sciences/Natur
DUNS #
041544081
City
Champaign
State
IL
Country
United States
Zip Code
61820