Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
1R29GM053660-01
Application #
2193045
Study Section
Human Embryology and Development Subcommittee 1 (HED)
Project Start
1996-03-01
Project End
2001-02-28
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Biochemistry
Type
Schools of Medicine
DUNS #
005436803
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Shi, Z Q; Yu, D H; Park, M et al. (2000) Molecular mechanism for the Shp-2 tyrosine phosphatase function in promoting growth factor stimulation of Erk activity. Mol Cell Biol 20:1526-36
Qu, C K; Yu, W M; Azzarelli, B et al. (1999) Genetic evidence that Shp-2 tyrosine phosphatase is a signal enhancer of the epidermal growth factor receptor in mammals. Proc Natl Acad Sci U S A 96:8528-33
Feng, G S (1999) Shp-2 tyrosine phosphatase: signaling one cell or many. Exp Cell Res 253:47-54
You, M; Yu, D H; Feng, G S (1999) Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathway. Mol Cell Biol 19:2416-24
Zhao, C; Yu, D H; Shen, R et al. (1999) Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1. J Biol Chem 274:19649-54
Shi, Z Q; Lu, W; Feng, G S (1998) The Shp-2 tyrosine phosphatase has opposite effects in mediating the activation of extracellular signal-regulated and c-Jun NH2-terminal mitogen-activated protein kinases. J Biol Chem 273:4904-8
Lu, X; Qu, C K; Shi, Z Q et al. (1998) Downregulation of platelet-derived growth factor receptor-beta in Shp-2 mutant fibroblast cell lines. Oncogene 17:441-8
Yu, D H; Qu, C K; Henegariu, O et al. (1998) Protein-tyrosine phosphatase Shp-2 regulates cell spreading, migration, and focal adhesion. J Biol Chem 273:21125-31
Qu, C K; Feng, G S (1998) Shp-2 has a positive regulatory role in ES cell differentiation and proliferation. Oncogene 17:433-9
Qu, C K; Yu, W M; Azzarelli, B et al. (1998) Biased suppression of hematopoiesis and multiple developmental defects in chimeric mice containing Shp-2 mutant cells. Mol Cell Biol 18:6075-82

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