Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29GM054909-06
Application #
6386638
Study Section
Medicinal Chemistry Study Section (MCHA)
Program Officer
Schwab, John M
Project Start
1996-07-01
Project End
2001-11-30
Budget Start
2001-07-01
Budget End
2001-11-30
Support Year
6
Fiscal Year
2001
Total Cost
$46,985
Indirect Cost
Name
University of California Irvine
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697
Ventocilla, Christian C; Woerpel, K A (2012) Synthesis of silyloxy dienes by silylene transfer to divinyl ketones: application to the asymmetric synthesis of substituted cyclohexanes. J Org Chem 77:3277-83
Greene, Margaret A; Prévost, Michel; Tolopilo, Joshua et al. (2012) Diastereoselective synthesis of seven-membered-ring trans-alkenes from dienes and aldehydes by silylene transfer. J Am Chem Soc 134:12482-4
Ventocilla, Christian C; Woerpel, K A (2011) Silylene-mediated polarity reversal of dienoates: additions of dienoates to aldehydes at the ?-position to form trans-dioxasilacyclononenes. J Am Chem Soc 133:406-8
Prevost, Michel; Ziller, Joseph W; Woerpel, K A (2010) Strained organosilacyclic compounds: synthesis of anti-Bredt olefins and trans-dioxasilacyclooctenes. Dalton Trans 39:9275-81
Ager, Bryan J; Bourque, Laura E; Buchner, Kay M et al. (2010) Silylene transfer to allylic sulfides: formation of substituted silacyclobutanes. J Org Chem 75:5729-32
Prevost, Michel; Woerpel, K A (2009) Insertions of silylenes into vinyl epoxides: diastereoselective synthesis of functionalized, optically active trans-dioxasilacyclooctenes. J Am Chem Soc 131:14182-3
Bourque, Laura E; Haile, Pamela A; Woerpel, K A (2009) Silylene-mediated ring contraction of homoallylic ethers to form allylic silanes. J Org Chem 74:7180-2
Buchner, Kay M; Clark, Timothy B; Loy, Janice M N et al. (2009) Alkylidenesilacyclopropanes derived from allenes: applications to the selective synthesis of triols and homoallylic alcohols. Org Lett 11:2173-5
Anderson, Laura L; Woerpel, K A (2009) Formation and utility of azasilacyclopentadienes derived from silacyclopropenes and nitriles. Org Lett 11:425-8