Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
1R29GM054911-01
Application #
2194224
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Project Start
1996-03-01
Project End
2001-02-28
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Surgery
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Hoesel, Laszlo M; Niederbichler, Andreas D; Schaefer, Julia et al. (2007) C5a-blockade improves burn-induced cardiac dysfunction. J Immunol 178:7902-10
Niederbichler, Andreas D; Westfall, Margaret V; Su, Grace L et al. (2006) Cardiomyocyte function after burn injury and lipopolysaccharide exposure: single-cell contraction analysis and cytokine secretion profile. Shock 25:176-83
Niederbichler, Andreas D; Hoesel, Laszlo M; Westfall, Margaret V et al. (2006) An essential role for complement C5a in the pathogenesis of septic cardiac dysfunction. J Exp Med 203:53-61
Steinstraesser, Lars; Burkhard, Olaf; Fan, Ming H et al. (2005) Burn wounds infected with Pseudomonas aeruginosa triggers weight loss in rats. BMC Surg 5:19
Steinstraesser, Lars; Alarcon, William; Fan, Ming-Hui et al. (2002) Thermal injury induces expression of CD14 in human skin. Burns 28:223-30
Fan, Ming-Hui; Klein, Richard D; Steinstraesser, Lars et al. (2002) An essential role for lipopolysaccharide-binding protein in pulmonary innate immune responses. Shock 18:248-54
Su, Grace L; Goyert, Sanna M; Fan, Ming-Hui et al. (2002) Activation of human and mouse Kupffer cells by lipopolysaccharide is mediated by CD14. Am J Physiol Gastrointest Liver Physiol 283:G640-5
Steinstraesser, Lars; Tack, Brian F; Waring, Alan J et al. (2002) Activity of novispirin G10 against Pseudomonas aeruginosa in vitro and in infected burns. Antimicrob Agents Chemother 46:1837-44
Steinstraesser, L; Klein, R D; Aminlari, A et al. (2001) Protegrin-1 enhances bacterial killing in thermally injured skin. Crit Care Med 29:1431-7
Su, G L; Klein, R D; Aminlari, A et al. (2000) Kupffer cell activation by lipopolysaccharide in rats: role for lipopolysaccharide binding protein and toll-like receptor 4. Hepatology 31:932-6

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