Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29HD028360-03
Application #
2201027
Study Section
Human Embryology and Development Subcommittee 1 (HED)
Project Start
1994-02-01
Project End
1999-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Ohio State University
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
098987217
City
Columbus
State
OH
Country
United States
Zip Code
43210
Xie, Y; Yang, S T; Kniss, D A (2001) Three-dimensional cell-scaffold constructs promote efficient gene transfection: implications for cell-based gene therapy. Tissue Eng 7:585-98
Kniss, D A; Rovin, B; Fertel, R H et al. (2001) Blockade NF-kappaB activation prohibits TNF-alpha-induced cyclooxygenase-2 gene expression in ED27 trophoblast-like cells. Placenta 22:80-9
Smith, A N; Carter, Q L; Kniss, D A et al. (2001) Characterization of a TGFbeta-responsive human trophoblast-derived cell line. Placenta 22:425-31
Kniss, D A (1999) Cyclooxygenases in reproductive medicine and biology. J Soc Gynecol Investig 6:285-92
Perkins, D J; Kniss, D A (1999) Blockade of nitric oxide formation down-regulates cyclooxygenase-2 and decreases PGE2 biosynthesis in macrophages. J Leukoc Biol 65:792-9
McKenna, D S; Samuels, P; Zimmerman, P D et al. (1998) Interleukin-1 alpha, epidermal growth factor, and transforming growth factor-beta exhibit differential kinetics on endothelin-1 synthesis in amnion cells. J Soc Gynecol Investig 5:25-30
Imseis, H M; Zimmerman, P D; Samuels, P et al. (1997) Tumour necrosis factor-alpha induces cyclo-oxygenase-2 gene expression in first trimester trophoblasts: suppression by glucocorticoids and NSAIDs. Placenta 18:521-6
Perkins, D J; Kniss, D A (1997) Tumor necrosis factor-alpha promotes sustained cyclooxygenase-2 expression: attenuation by dexamethasone and NSAIDs. Prostaglandins 54:727-43
Swaisgood, C M; Zu, H X; Perkins, D J et al. (1997) Coordinate expression of inducible nitric oxide synthase and cyclooxygenase-2 genes in uterine tissues of endotoxin-treated pregnant mice. Am J Obstet Gynecol 177:1253-62
Perkins, D J; Kniss, D A (1997) Rapid and transient induction of cyclo-oxygenase 2 by epidermal growth factor in human amnion-derived WISH cells. Biochem J 321 ( Pt 3):677-81

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