This research program attempts to improve the current understanding of the transport phenomena of macromolecular solutes in sheared suspensions undergoing laminar flow. Using the technique of internal reflection fluorescence (IRF), augmented mass transfer will be determined using a rotating disc flow system. The diffusion coefficients of several macromolecular solutes will be measured in aqueous suspensions as a function of suspension particle volume fraction, shear rate, suspension viscosity/viscoelasticity, particle size, particle rigidity, and shear rate. This proposal intends to identify and characterize the important experimental parameters and to clarify mechanisms involved in enhancing the diffusivities of macromolecular solutes in sheared suspensions.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
1R29HL039856-01A1
Application #
3471813
Study Section
Surgery and Bioengineering Study Section (SB)
Project Start
1989-05-01
Project End
1994-04-30
Budget Start
1989-05-01
Budget End
1990-04-30
Support Year
1
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Illinois Institute of Technology
Department
Type
Biomed Engr/Col Engr/Engr Sta
DUNS #
City
Chicago
State
IL
Country
United States
Zip Code
60616