We plan to assess the prevalence of carotid artery disease in a healthy population of 200 elderly adults with isolated systolic hypertension and 200 normotensive controls matched for age and sex. Carotid disease will be assessed by duplex scanning, a noninvasive technique that combines real time B-mode ultrasound with Doppler ultrasound, producing a system capable of both vessel imaging and analysis of blood flow characteristics. Other evaluations to be done include ankle systolic blood pressure measurements to detect lower extremity arterial disease, complete history and physical examination, EKG, blood lipoprotein levels, fasting insulin and glucose levels, hemoglobin, and hematocrit. We will thus be able to evaluate the effect of various risk factors on the development of carotid atherosclerosis. We will also be able to evaluate the relationship between carotid atherosclerosis and atherosclerotic disease of the lower extremities. The first 6 months of the study will consist of preparation and further reproducibility testing of duplex scan measurements. During the following 3 years, duplex scans as well as other evaluations will be completed on all 400 participants. During the final half of the fourth year, the first 100 duplex scans of hypertensive participants will be repeated. These repeat scans will be evaluated to determine whether our methodology can detect carotid disease progression. The final year of the study will consist of data analysis and preparation of final manuscripts.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29HL039871-05
Application #
3471833
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Project Start
1988-07-01
Project End
1993-06-30
Budget Start
1992-07-01
Budget End
1993-06-30
Support Year
5
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Type
Schools of Public Health
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Wildman, Rachel P; Sutton-Tyrrell, Kim; Newman, Anne B et al. (2004) Lipoprotein levels are associated with incident hypertension in older adults. J Am Geriatr Soc 52:916-21
Sutton-Tyrrell, K; Bostom, A; Selhub, J et al. (1997) High homocysteine levels are independently related to isolated systolic hypertension in older adults. Circulation 96:1745-9
Franklin, S S; Sutton-Tyrrell, K; Belle, S H et al. (1997) The importance of pulsatile components of hypertension in predicting carotid stenosis in older adults. J Hypertens 15:1143-50
Sutton-Tyrrell, K; Alcorn, H G; Herzog, H et al. (1995) Morbidity, mortality, and antihypertensive treatment effects by extent of atherosclerosis in older adults with isolated systolic hypertension. Stroke 26:1319-24
Sutton-Tyrrell, K; Wolfson Jr, S K; Kuller, L H (1994) Blood pressure treatment slows the progression of carotid stenosis in patients with isolated systolic hypertension. Stroke 25:44-50
Sutton-Tyrrell, K; Alcorn, H G; Wolfson Jr, S K et al. (1993) Predictors of carotid stenosis in older adults with and without isolated systolic hypertension. Stroke 24:355-61
Sutton-Tyrrell, K; Wolfson Jr, S K; Thompson, T et al. (1992) Measurement variability in duplex scan assessment of carotid atherosclerosis. Stroke 23:215-20
Sparrow, D; O'Connor, G T; Rosner, B et al. (1991) Methacholine airway responsiveness and 24-hour urine excretion of sodium and potassium. The Normative Aging Study. Am Rev Respir Dis 144:722-5