The proposed research will integrate experimental and theoretical descriptions of the dosimetry of laser and conventional light sources for therapeutic and diagnostic applications in medicine. One goal is the development of experimental techniques to specify tissue optical properties, and measurement of a variety of tissue types to yield a LIBRARY of tissue optical properties over the ultraviolet-visible-near infrared spectrum. A second goal is COMPUTER SIMULATION OF RADIATIVE TRANSPORT in complex turbid tissues. Steady-state dosimetry will be studied in homogeneous and heterogeneous tissues for variable boundary conditions and geometries of irradiation. Time-variant dosimetry will be studied in which thermally induced changes in tissue optical properties dynamically alter dosimetry during the laser exposure. The research involves computer simulations, phantom tissue models, and in vitro and in vivo animal experiments. The research goals would aid the development of therapeutic protocols and optical devices for dosimetry and diagnostics. Three clinical situations will be considered to focus the general concepts: (1) laser therapy of portwine stain lesions, (2) screening pigmented nevi for melanoma. and (3) NdYAG irradiation of bladder and prostate during surface cooling by irrigation. The work will be conducted in a basic research laboratory within a hospital environment and motivated to yield information pertinent to practical clinical applications.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
First Independent Research Support & Transition (FIRST) Awards (R29)
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Radiation Study Section (RAD)
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University of Texas MD Anderson Cancer Center
Other Domestic Higher Education
United States
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Jacques, Steven L (2010) How tissue optics affect dosimetry of photodynamic therapy. J Biomed Opt 15:051608
Jacques, S L (1998) Light distributions from point, line and plane sources for photochemical reactions and fluorescence in turbid biological tissues. Photochem Photobiol 67:23-32
Jacques, S L (1998) Path integral description of light transport in tissue. Ann N Y Acad Sci 838:1-13
Wang, L; Jacques, S L; Zheng, L (1997) CONV--convolution for responses to a finite diameter photon beam incident on multi-layered tissues. Comput Methods Programs Biomed 54:141-50
Ostermeyer, M R; Jacques, S L (1997) Perturbation theory for diffuse light transport in complex biological tissues. J Opt Soc Am A Opt Image Sci Vis 14:255-61
Gardner, C M; Jacques, S L; Welch, A J (1996) Light transport in tissue: Accurate expressions for one-dimensional fluence rate and escape function based upon monte carlo simulation. Lasers Surg Med 18:129-38
Oraevsky, A A; Jacques, S L; Esenaliev, R O et al. (1996) Pulsed laser ablation of soft tissues, gels, and aqueous solutions at temperatures below 100 degrees C. Lasers Surg Med 18:231-40
Wang, L; Jacques, S L; Zheng, L (1995) MCML--Monte Carlo modeling of light transport in multi-layered tissues. Comput Methods Programs Biomed 47:131-46
Gostout, C J; Jacques, S L (1995) Infrared video imaging of subsurface vessels: a feasibility study for the endoscopic management of gastrointestinal bleeding. Gastrointest Endosc 41:218-24
Hielscher, A H; Jacques, S L; Wang, L et al. (1995) The influence of boundary conditions on the accuracy of diffusion theory in time-resolved reflectance spectroscopy of biological tissues. Phys Med Biol 40:1957-75

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