Structure Function Studies for Thrombin and Fibrinogen

Henriksen, Ruth A.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Heart, Lung, and Blood Institute (NHLBI)
• Type: First Independent Research Support & Transition (FIRST) Awards (R29)
• Project #: 5R29HL045194-05
• Application #: 2221995
• Study Section: Hematology Subcommittee 2 (HEM)
• Project Start: 1991-07-25
• Project End: 1998-06-30
• Budget Start: 1996-07-01
• Budget End: 1998-06-30
• Support Year: 5
• Fiscal Year: 1996

Institution

• Name: East Carolina University
• Department: Internal Medicine/Medicine
• Type: Schools of Medicine
• City: Greenville
• State: NC
• Country: United States
• Zip Code: 27858

Publications

Jenkins, P V; Pasi, K J; Perkins, S J (1998) Molecular modeling of ligand and mutation sites of the type A domains of human von Willebrand factor and their relevance to von Willebrand's disease. Blood 91:2032-44

Hayes, K L; Leong, L; Henriksen, R A et al. (1994) alpha-Thrombin-induced human platelet activation results solely from formation of a specific enzyme-substrate complex. J Biol Chem 269:28606-12

Henriksen, R A (1993) Identification and characterization of mutant thrombins. Methods Enzymol 222:312-27

Phillips, J E; Shirk, R A; Whinna, H C et al. (1993) Inhibition of dysthrombins Quick I and II by heparin cofactor II and antithrombin. J Biol Chem 268:3321-7