Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29HL049136-03
Application #
2225244
Study Section
Respiratory and Applied Physiology Study Section (RAP)
Project Start
1994-04-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Veterinary Sciences
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Brieland, J K; Remick, D G; LeGendre, M L et al. (1998) In vivo regulation of replicative Legionella pneumophila lung infection by endogenous interleukin-12. Infect Immun 66:65-9
Brieland, J K; Fantone, J C; Remick, D G et al. (1997) The role of Legionella pneumophila-infected Hartmannella vermiformis as an infectious particle in a murine model of Legionnaire's disease. Infect Immun 65:5330-3
Brieland, J; McClain, M; LeGendre, M et al. (1997) Intrapulmonary Hartmannella vermiformis: a potential niche for Legionella pneumophila replication in a murine model of legionellosis. Infect Immun 65:4892-6
Heath, L; Chrisp, C; Huffnagle, G et al. (1996) Effector mechanisms responsible for gamma interferon-mediated host resistance to Legionella pneumophila lung infection: the role of endogenous nitric oxide differs in susceptible and resistant murine hosts. Infect Immun 64:5151-60
Brieland, J; McClain, M; Heath, L et al. (1996) Coinoculation with Hartmannella vermiformis enhances replicative Legionella pneumophila lung infection in a murine model of Legionnaires' disease. Infect Immun 64:2449-56
Brieland, J K; Heath, L A; Huffnagle, G B et al. (1996) Humoral immunity and regulation of intrapulmonary growth of Legionella pneumophila in the immunocompetent host. J Immunol 157:5002-8
Brieland, J K; Flory, C M; Jones, M L et al. (1995) Regulation of monocyte chemoattractant protein-1 gene expression and secretion in rat pulmonary alveolar macrophages by lipopolysaccharide, tumor necrosis factor-alpha, and interleukin-1 beta. Am J Respir Cell Mol Biol 12:104-9
Brieland, J K; Remick, D G; Freeman, P T et al. (1995) In vivo regulation of replicative Legionella pneumophila lung infection by endogenous tumor necrosis factor alpha and nitric oxide. Infect Immun 63:3253-8