Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29HL049954-04
Application #
2226022
Study Section
Nutrition Study Section (NTN)
Project Start
1993-06-01
Project End
1997-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Boston University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
Frei, B; McCall, M R (2001) Antioxidant vitamins: evidence from biomarkers in humans. Bibl Nutr Dieta :46-67
McCall, M R; Carr, A C; Forte, T M et al. (2001) Ldl modified by hypochlorous acid is a potent inhibitor of lecithin-cholesterol acyltransferase activity. Arterioscler Thromb Vasc Biol 21:1040-5
Chen, K; Suh, J; Carr, A C et al. (2000) Vitamin C suppresses oxidative lipid damage in vivo, even in the presence of iron overload. Am J Physiol Endocrinol Metab 279:E1406-12
Carr, A; Frei, B (1999) Does vitamin C act as a pro-oxidant under physiological conditions? FASEB J 13:1007-24
Gokce, N; Keaney Jr, J F; Frei, B et al. (1999) Long-term ascorbic acid administration reverses endothelial vasomotor dysfunction in patients with coronary artery disease. Circulation 99:3234-40
Retsky, K L; Chen, K; Zeind, J et al. (1999) Inhibition of copper-induced LDL oxidation by vitamin C is associated with decreased copper-binding to LDL and 2-oxo-histidine formation. Free Radic Biol Med 26:90-8
Shwaery, G T; Samii, J M; Frei, B et al. (1999) Determination of phospholipid oxidation in cultured cells. Methods Enzymol 300:51-7
Carr, A C; Frei, B (1999) Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans. Am J Clin Nutr 69:1086-107
McCall, M R; Frei, B (1999) Can antioxidant vitamins materially reduce oxidative damage in humans? Free Radic Biol Med 26:1034-53
Berger, T M; Frei, B; Rifai, N et al. (1998) Early high dose antioxidant vitamins do not prevent bronchopulmonary dysplasia in premature baboons exposed to prolonged hyperoxia: a pilot study. Pediatr Res 43:719-26

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