Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29HL053601-02
Application #
2231615
Study Section
Pathology A Study Section (PTHA)
Project Start
1994-12-01
Project End
1998-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Pathology
Type
Schools of Dentistry
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Park, H; Go, Y M; Darji, R et al. (2000) Caveolin-1 regulates shear stress-dependent activation of extracellular signal-regulated kinase. Am J Physiol Heart Circ Physiol 278:H1285-93
Go, Y M; Patel, R P; Maland, M C et al. (1999) Evidence for peroxynitrite as a signaling molecule in flow-dependent activation of c-Jun NH(2)-terminal kinase. Am J Physiol 277:H1647-53
Moellering, D; Mc Andrew, J; Patel, R P et al. (1999) The induction of GSH synthesis by nanomolar concentrations of NO in endothelial cells: a role for gamma-glutamylcysteine synthetase and gamma-glutamyl transpeptidase. FEBS Lett 448:292-6
Go, Y M; Park, H; Maland, M C et al. (1999) In vitro system to study role of blood flow on nitric oxide production and cell signaling in endothelial cells. Methods Enzymol 301:513-22
Moellering, D; McAndrew, J; Patel, R P et al. (1998) Nitric oxide-dependent induction of glutathione synthesis through increased expression of gamma-glutamylcysteine synthetase. Arch Biochem Biophys 358:74-82
Go, Y M; Park, H; Maland, M C et al. (1998) Phosphatidylinositol 3-kinase gamma mediates shear stress-dependent activation of JNK in endothelial cells. Am J Physiol 275:H1898-904
Engelman, J A; Chu, C; Lin, A et al. (1998) Caveolin-mediated regulation of signaling along the p42/44 MAP kinase cascade in vivo. A role for the caveolin-scaffolding domain. FEBS Lett 428:205-11
Park, H; Go, Y M; St John, P L et al. (1998) Plasma membrane cholesterol is a key molecule in shear stress-dependent activation of extracellular signal-regulated kinase. J Biol Chem 273:32304-11
Jo, H; Sipos, K; Go, Y M et al. (1997) Differential effect of shear stress on extracellular signal-regulated kinase and N-terminal Jun kinase in endothelial cells. Gi2- and Gbeta/gamma-dependent signaling pathways. J Biol Chem 272:1395-401