Abstract

The kinetics of I-131 labeled meta-iodobenzylguanidine (MIBG) in the heart will be studied using an isolated perfused rat heart model. Uptake, retention and release of I-131-MIBG will be studied under various conditions and correlated with variables such as catecholamine transport and metabolism, ischemia, and variations in cardiac metabolic substrate. Neuronal and extraneuronal uptake will be distinguished using agents that block specific uptake pathways. A comprehensive mathematical model of MIBG kinetics in the heart will be developed. The goal is to define the physiologic mechanisms that govern uptake of MIBG in the heart. The investigations will attempt to clarify the role of specific transporters and binding sites and seek to define the relationship of these processes to 1) the kinetic behavior observed by external monitoring techniques, and 2) the corresponding disposition of endogenous catecholamines in normal and ischemic conditions.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29HL054882-03
Application #
2735273
Study Section
Diagnostic Radiology Study Section (RNM)
Project Start
1996-07-01
Project End
2000-06-30
Budget Start
1998-07-01
Budget End
1999-06-30
Support Year
3
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Duke University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705