Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29HL054897-02
Application #
2233399
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Project Start
1995-09-22
Project End
1999-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Harvard University
Department
Type
Schools of Public Health
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
Russell, M E (2000) Cardiac allograft vasculopathy--a changing perspective. Z Kardiol 89 Suppl 9:IX/6-10
Grimm, P C; McKenna, R; Nickerson, P et al. (1999) Clinical rejection is distinguished from subclinical rejection by increased infiltration by a population of activated macrophages. J Am Soc Nephrol 10:1582-9
Raisanen-Sokolowski, A; Glysing-Jensen, T; Russell, M E (1999) Donor and recipient contributions of ICAM-1 and P-selectin in parenchymal rejection and graft arteriosclerosis: insights from double knockout mice. J Heart Lung Transplant 18:735-43
Glysing-Jensen, T; Raisanen-Sokolowski, A; Sayegh, M H et al. (1997) Chronic blockade of CD28-B7-mediated T-cell costimulation by CTLA4Ig reduces intimal thickening in MHC class I and II incompatible mouse heart allografts. Transplantation 64:1641-5
Raisanen-Sokolowski, A; Glysing-Jensen, T; Mottram, P L et al. (1997) Sustained anti-CD4/CD8 treatment blocks inflammatory activation and intimal thickening in mouse heart allografts. Arterioscler Thromb Vasc Biol 17:2115-22
Russell, M E; Raisanen-Sokolowski, A; Mottram, P et al. (1997) Knockout models of chronic cardiac rejection and graft arteriosclerosis: intimal thickening develops independent of Th1 and Th2 cytokines. Transplant Proc 29:2531-2
Raisanen-Sokolowski, A; Mottram, P L; Glysing-Jensen, T et al. (1997) Heart transplants in interferon-gamma, interleukin 4, and interleukin 10 knockout mice. Recipient environment alters graft rejection. J Clin Invest 100:2449-56