The objective of this proposal is to understand the adaptive mechanisms in the structure, mechanical properties and function of the coronary arterial vessels to altered mechanical forces, including principal and shear stresses, in experimental models of hypertension and flow overload.
The specific aims i nclude studies on alterations in the macro-structure including the length, diameter, and branching pattern of all generations of the coronary tree in response to increased mechanical stresses; alterations in the vessel walls and their micro-structure, including the intima, media and adventitia of all generations; to determine the remodeling of the mechanical properties, including the zero-stress state; and to express the structural and mechanical remodeling data mathematically in terms of indicial functions. This project will provide a structural and mechanical foundation for the study of tissue engineering of the blood vessels, to clarify the role of mechanical stresses on coronary blood vessel remodeling, and to clarify the structural and mechanical remodeling that signifies hypertension and hypertrophy as important risk factors for coronary artery disease.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
First Independent Research Support & Transition (FIRST) Awards (R29)
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Surgery and Bioengineering Study Section (SB)
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University of California San Diego
Biomedical Engineering
Schools of Arts and Sciences
La Jolla
United States
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Young, Jonathan M; Choy, Jenny S; Kassab, Ghassan S et al. (2012) Slackness between vessel and myocardium is necessary for coronary flow reserve. Am J Physiol Heart Circ Physiol 302:H2230-42
Lu, Deshun; Kassab, Ghassan S (2011) Role of shear stress and stretch in vascular mechanobiology. J R Soc Interface 8:1379-85
Lu, Xiao; Dang, Charles Q; Guo, Xiaomei et al. (2011) Elevated oxidative stress and endothelial dysfunction in right coronary artery of right ventricular hypertrophy. J Appl Physiol (1985) 110:1674-81
Algranati, Dotan; Kassab, Ghassan S; Lanir, Yoram (2011) Why is the subendocardium more vulnerable to ischemia? A new paradigm. Am J Physiol Heart Circ Physiol 300:H1090-100
Lu, Xiao; Kassab, Ghassan S (2011) Assessment of endothelial function of large, medium, and small vessels: a unified myograph. Am J Physiol Heart Circ Physiol 300:H94-H100
Kaimovitz, Benjamin; Lanir, Yoram; Kassab, Ghassan S (2010) A full 3-D reconstruction of the entire porcine coronary vasculature. Am J Physiol Heart Circ Physiol 299:H1064-76
Algranati, Dotan; Kassab, Ghassan S; Lanir, Yoram (2010) Mechanisms of myocardium-coronary vessel interaction. Am J Physiol Heart Circ Physiol 298:H861-73
Wang, Chong; Guo, Xiaomei; Kassab, Ghassan S (2009) A new observation on the stress distribution in the coronary artery wall. J Biomech Eng 131:111011
Chen, Henry Y; Navia, Jose A; Kassab, Ghassan S (2009) A simulation of vessel-clamp interaction: transient closure dynamics. Ann Biomed Eng 37:1772-80
Kumagai, Robert; Lu, Xiao; Kassab, Ghassan S (2009) Role of glycocalyx in flow-induced production of nitric oxide and reactive oxygen species. Free Radic Biol Med 47:600-7

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