This is a revised first award that will investigate the role of adenosine in regulating blood flow in the renal medulla.
The specific aims are to examine the role of cAMP in mediating A1 and A2 agonists on the diameter of isolated perfused vasa recta capillaries; 2) to determine the effects of renal ischemia on adenosine levels in the renal medulla and on medullary blood flow in vivo; 3) to determine the effects of changes in sodium diet on renal adenosine levels and regional blood flow in the kidney and; 4) to map adenosine receptor subtypes in tubular and vascular structures in the renal medulla. These studies should contribute important new information regarding the role of adenosine in the control of medullary blood flow and oxygen delivery to the renal medulla which plays a critical role in the mechanism of urine concentration, sodium and water excretion, and the control of arterial pressure.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29HL057329-03
Application #
6228951
Study Section
Cardiovascular and Renal Study Section (CVB)
Project Start
1997-12-01
Project End
2001-11-30
Budget Start
2000-02-18
Budget End
2000-11-30
Support Year
3
Fiscal Year
2000
Total Cost
$106,236
Indirect Cost
Name
Towson University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
143372741
City
Towson
State
MD
Country
United States
Zip Code
21252
Silldorff, Erik P; Hilbun, Layla R; Pallone, Thomas L (2002) Angiotensin II constriction of rat vasa recta is partially thromboxane dependent. Hypertension 40:541-6
Edwards, A; Silldforff, E P; Pallone, T L (2000) The renal medullary microcirculation. Front Biosci 5:E36-52