Impairments in the learning and memory of even the simplest of tasks can be extremely disruptive to normal functioning and, in the long term, affect both mental and physical health. To fully understand impairments of learning and memory, it is necessary to understand how the brain alters activity to produce learning and memory. To this end, the long term goal of the proposed research is to described neuronal mechanisms and processes that form the basis of simple forms of learning and memory. More specifically, the proposed experiments are designed to study of the involvement the cerebellar deep nuclei (i.e., the interpositus nucleus) in classical conditioning, a simple form of motor learning. Three phases of experimentation are proposed: 1) a characterization of the patterns of critical sitmulus inputs the interpositus nucleus, 2) a description of potential alterations of activity of the interpositus nucleus during classical conditioning, 3) the development of a reduced preparation amenale to future intracellular study of neuronal mechanisms involved in classical conditioning. In all three phases of the proposed experimentation, extracellular field potentials and single unit acitivity evoked by stimulation of precerebellar afferents will be monitored to assess imterpositus activity. It is anticipated that these studies will provide valuable data concerning activity of the interpositus nucleus during classical conditioning.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29MH044052-04
Application #
3474971
Study Section
Neurosciences Research Review Committee (BPN)
Project Start
1988-09-30
Project End
1993-08-31
Budget Start
1991-09-01
Budget End
1992-08-31
Support Year
4
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Indiana University Bloomington
Department
Type
Schools of Arts and Sciences
DUNS #
006046700
City
Bloomington
State
IN
Country
United States
Zip Code
47401
Miller, D P; Steinmetz, J E (1997) Hippocampal activity during classical discrimination--reversal eyeblink conditioning in rabbits. Behav Neurosci 111:70-9
Sears, L L; Steinmetz, J E (1997) Effects of haloperidol on sensory processing in the hippocampus during classical eyeblink conditioning. Psychopharmacology (Berl) 130:254-60
Sears, L L; Logue, S F; Steinmetz, J E (1996) Involvement of the ventrolateral thalamic nucleus in rabbit classical eyeblink conditioning. Behav Brain Res 74:105-17
Gould, T J; Steinmetz, J E (1996) Changes in rabbit cerebellar cortical and interpositus nucleus activity during acquisition, extinction, and backward classical eyelid conditioning. Neurobiol Learn Mem 65:17-34
Anderson, B J; Steinmetz, J E (1994) Cerebellar and brainstem circuits involved in classical eyeblink conditioning. Rev Neurosci 5:251-73
Sears, L L; Finn, P R; Steinmetz, J E (1994) Abnormal classical eye-blink conditioning in autism. J Autism Dev Disord 24:737-51
Gould, T J; Steinmetz, J E (1994) Multiple-unit activity from rabbit cerebellar cortex and interpositus nucleus during classical discrimination/reversal eyelid conditioning. Brain Res 652:98-106
White, I M; Miller, D P; White, W et al. (1994) Neuronal activity in rabbit neostriatum during classical eyelid conditioning. Exp Brain Res 99:179-90
Steinmetz, J E; Logue, S F; Miller, D P (1993) Using signaled barpressing tasks to study the neural substrates of appetitive and aversive learning in rats: behavioral manipulations and cerebellar lesions. Behav Neurosci 107:941-54
Gould, T J; Sears, L L; Steinmetz, J E (1993) Possible CS and US pathways for rabbit classical eyelid conditioning: electrophysiological evidence for projections from the pontine nuclei and inferior olive to cerebellar cortex and nuclei. Behav Neural Biol 60:172-85

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