Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29MH044275-05
Application #
2246052
Study Section
Neurosciences Research Review Committee (BPN)
Project Start
1988-08-01
Project End
1994-07-31
Budget Start
1992-08-01
Budget End
1994-07-31
Support Year
5
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Psychiatry
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Friedman, E M; Irwin, M R; Overstreet, D H (1996) Natural and cellular immune responses in Flinders sensitive and resistant line rats. Neuropsychopharmacology 15:314-22
Friedman, E M; Irwin, M R (1995) A role for CRH and the sympathetic nervous system in stress-induced immunosuppression. Ann N Y Acad Sci 771:396-418
Zisook, S; Shuchter, S R; Irwin, M et al. (1994) Bereavement, depression, and immune function. Psychiatry Res 52:1-10
Cover, H; Irwin, M (1994) Immunity and depression: insomnia, retardation, and reduction of natural killer cell activity. J Behav Med 17:217-23
Irwin, M (1994) Stress-induced immune suppression: role of brain corticotropin releasing hormone and autonomic nervous system mechanisms. Adv Neuroimmunol 4:29-47
Irwin, M (1993) Brain corticotropin-releasing hormone- and interleukin-1 beta-induced suppression of specific antibody production. Endocrinology 133:1352-60
Hauger, R L; Irwin, M R; Lorang, M et al. (1993) High intracerebral levels of CRH result in CRH receptor downregulation in the amygdala and neuroimmune desensitization. Brain Res 616:283-92
Irwin, M (1993) Stress-induced immune suppression. Role of the autonomic nervous system. Ann N Y Acad Sci 697:203-18
Irwin, M; Hauger, R L; Britton, K (1993) Benzodiazepines antagonize central corticotropin releasing hormone-induced suppression of natural killer cell activity. Brain Res 631:114-8
Irwin, M; Hauger, R; Brown, M (1992) Central corticotropin-releasing hormone activates the sympathetic nervous system and reduces immune function: increased responsivity of the aged rat. Endocrinology 131:1047-53

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